Results 11 to 20 of about 15,357 (224)

TFEB Biology and Agonists at a Glance [PDF]

Cells, 2021
Autophagy is a critical regulator of cellular survival, differentiation, development, and homeostasis, dysregulation of which is associated with diverse diseases including cancer and neurodegenerative diseases.

exaly   +6 more sources

PIKFYVE-dependent regulation of MTORC1 and TFEB

Autophagy Reports, 2022
TFEB (transcription factor EB) is essential for the upregulation of gene expression required for macroautophagy/autophagy and lysosomal function. Under nutrient-rich conditions, TFEB is inactivated by MTOR (mechanistic target of rapamycin kinase) complex
Junya Hasegawa, Ken Inoki, Lois S. Weisman   +2 more
doaj   +4 more sources

TFEB at a glance [PDF]

Journal of Cell Science, 2016
ABSTRACT The transcription factor EB (TFEB) plays a pivotal role in the regulation of basic cellular processes, such as lysosomal biogenesis and autophagy. The subcellular localization and activity of TFEB are regulated by mechanistic target of rapamycin (mTOR)-mediated phosphorylation, which occurs at the lysosomal surface ...
BALLABIO, ANDREA, Napolitano, Gennaro
openaire   +5 more sources

A splicing variant of TFEB negatively regulates the TFEB-autophagy pathway [PDF]

Scientific Reports, 2021
Transcription factor EB (TFEB) is a master regulator of the autophagy-lysosomal pathway (ALP). Here, we cloned a novel splicing variant of TFEB, comprising 281 amino acids (hereafter referred to as small TFEB), and lacking the helix-loop-helix (HLH) and ...
Jee-Yun Park, Hee-Young Sohn, Young Ho Koh, Chulman Jo   +3 more
doaj   +3 more sources

A prion-like domain of TFEB mediates the co-aggregation of TFEB and mHTT

Autophagy, 2022
The aggregation of mutant HTT (huntingtin; mHTT) is a hallmark of Huntington disease (HD). mHTT aggregates interact and sequester dozens of proteins and affect diverse key cellular functions. Here we report that TFEB (transcription factor EB), a master regulator of lysosome biogenesis and autophagy, is yet another protein that co-aggregates with mHTT ...
Junsheng Yang, Huilin Xu, Chaoyue Zhang, Xiaotong Yang, Weijie Cai, Xiaoli Chen   +5 more
openaire   +3 more sources

TFEB regulates lysosomal proteostasis [PDF]

Human Molecular Genetics, 2013
Loss-of-function diseases are often caused by destabilizing mutations that lead to protein misfolding and degradation. Modulating the innate protein homeostasis (proteostasis) capacity may lead to rescue of native folding of the mutated variants, thereby ameliorating the disease phenotype.
Song, Wensi, Wang, Fan, Savini, Marzia, Ake, Ashley, di Ronza, Alberto, Sardiello, Marco, Segatori, Laura   +6 more
openaire   +4 more sources

TFEB Signalling-Related MicroRNAs and Autophagy [PDF]

Biomolecules, 2021
The oncogenic Transcription Factor EB (TFEB), a member of MITF-TFE family, is known to be the most important regulator of the transcription of genes responsible for the control of lysosomal biogenesis and functions, autophagy, and vesicles flux. TFEB activation occurs in response to stress factors such as nutrient and growth factor deficiency, hypoxia,
Corà, Davide, Bussolino, Federico, Doronzo, Gabriella   +2 more
openaire   +7 more sources

TFEB rearranged renal cell carcinoma. A clinicopathologic and molecular study of 13 cases. Tumors harboring MALAT1-TFEB, ACTB-TFEB, and the novel NEAT1-TFEB translocations constantly express PDL1

Modern Pathology, 2021
Renal cell carcinomas with t(6;11) chromosome translocation has been classically characterized by the rearrangement of the TFEB gene, located on chromosome 6, and MALAT1 gene, located on chromosome 11. Recently, a few other genes have been described as fusion partners in TFEB rearranged renal cell carcinomas. Although most of TFEB rearranged renal cell
Anna Caliò, Shuko Harada, Matteo Brunelli, Serena Pedron, Diego Segala, Sofia Canete Portillo, Cristina Magi-Galluzzi, George J. Netto, Alexander C. Mackinnon, Guido Martignoni   +9 more
openaire   +3 more sources

Role of TFEB in Autophagy and the Pathogenesis of Liver Diseases

Biomolecules, 2022
The transcription factor EB (TFEB) is a master regulator of lysosomal function and autophagy. Mechanistic target of rapamycin (mTOR)-mediated phosphorylation on TFEB is known to regulate TFEB subcellular localization and activity at the lysosomal surface.
Shengmin Yan
exaly   +3 more sources

Regulation of MITF and TFEB [PDF]

, 2016
The bHLH-LZ transcription factors MITF and TFEB have been implicated in human disease, with their overexpression increasing the risk of developing cancer. The manner in which their access to E-box target motifs is controlled is an important consideration, as it is via binding to these motifs that bHLH-LZ factors mediate changes in gene expression.
Hans Friedrichsen, Friedrichsen, Hans
openaire   +2 more sources