Results 61 to 70 of about 4,631,251 (249)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Deregulation of sucrose-controlled translation of a bZIP-type transcription factor results in sucrose accumulation in leaves [PDF]

, 2011
Sucrose is known to repress the translation of Arabidopsis thaliana AtbZIP11 transcript which encodes a protein belonging to the group of S (S - stands for small) basic region-leucine zipper (bZIP)-type transcription factor.
Sunil Kumar Thalor, Xujun Zhu, Thomas Berberich (176654), Imai Ryozo, Ryozo Imai, Tomonobu Kusano (176673), Zhu XuJun, Imai, Ryozo, Tomonobu Kusano, Berberich Thomas, Takahashi, Yoshihiro, Seung Hwan Yang, Takahashi Yoshihiro, Yang, Seung Hwan, Yang Seung Hwan, Kusano, Tomonobu, Berberich, Thomas, Sunil Kumar Thalor (176650), Sung Shin Lee (176658), Thalor, Sunil Kumar, Lee, Sung Shin, Zhu, XuJun, Yoshihiro Takahashi, Lee Sung Shin, Sung Shin Lee, Kusano Tomonobu, Ryozo Imai (176667), Thomas Berberich, Seung Hwan Yang (176661), Yoshihiro Takahashi (176670), Thalor Sunil Kumar, XuJun Zhu (176664)   +31 more
core   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo [PDF]

, 2006
The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus.
Freeman, Tom, Herbert, Mark, Hasegawa, Hitoshi, Willinger, Tim, Callan, Margaret F C, McMichael, Andrew J   +5 more
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Statistical reconstruction of transcription factor activity using Michaelis-Menten kinetics [PDF]

, 2007
Summary. The basic building block of a gene regulatory network consists of a gene encoding a transcription factor (TF) and the gene(s) it regulates. Considerable efforts have been directed recently at devising experiments and algorithms to determine TFs
Smith, C.P.,, Smith, C.P., Vinciotti, V., Smith, C P, Khanin, R.,, Khanin, Raya, Mersinias, V., Wit, E.,, Vinciotti, V.,, Wit, Ernst, Vinciotti, V, Mersinias, V.,, Mersinias, V, Smith, CP, Khanin, R, Wit, E, Khanin, R.   +16 more
core   +1 more source

Iterative Selection of DNA Nanostructures for Cellular Uptake

Advanced Materials, EarlyView.
DNA nanostructures are promising cell targeting delivery vehicles for therapeutics, but the targeting behavior is not fully understood. In this study, libraries of DNA nanostructures that can be amplified and sequenced are combined with cellular uptake as a selection pressure to iteratively refine DNA structures taken up in cells to better understand ...
Anjali Rajwar, Lisa Eichhorn, Jakub Palacka, Sandra Ly, Erik Benson   +4 more
wiley   +1 more source

Downregulation of transcription factor EB inhibits the growth and metastasis of colorectal carcinomas

European Journal of Inflammation, 2018
To determine the roles of transcription factor EB (TFEB) in colorectal cancer (CRC), we collected samples of tumor tissues and normal tissues from 40 patients with CRC.
Jin-Zhe Chang, Shu-Dong Chen, Hui Zheng, Hua-Ping Zhang   +3 more
doaj   +1 more source

Overexpression of transcription factor EB regulates mitochondrial autophagy to protect lipopolysaccharide-induced acute lung injury

Chinese Medical Journal, 2019
. Background:. Acute lung injury (ALI) is characterized by an acute inflammatory process, and oxidative stress in the lung tissue leads to a lack of effective therapeutics.
Wei Liu, Cong-Cong Li, Xi Lu, Li-Yan Bo, Fa-Guang Jin, Yi Cui   +5 more
doaj   +1 more source

Arabidopsis HEAT SHOCK TRANSCRIPTION FACTORA1b overexpression enhances water productivity, resistance to drought, and infection [PDF]

, 2013
Heat-stressed crops suffer dehydration, depressed growth, and a consequent decline in water productivity, which is the yield of harvestable product as a function of lifetime water consumption and is a trait associated with plant growth and development ...
Schöffl, F., Hickman, Richard D. G., Sparrow, Penelope A.C., Albihlal, Waleed S, Lawson, Tracy, Sparrow, P.A.C., Persad, R., Beynon, Jim L., Sparrow, Penelope A. C., Persad, Ramona, Bowden, L., Ott, S., Beynon, Jim L, Hickman, Richard, Bechtold, Ulrike, Beynon, Jim, Baker, Neil R, Mullineaux, Philip M., Schoeffl, Friedrich, Bechtold, U., Schoffl, Friedrich, Baker, N. R., Morison, J.L., Richard, F., Bowden, Laura, Mullineaux, Philip M, Mullineaux, P.M., Martin, Cathie, Albihlal, W.S., Fryer, Michael J., Buchanan-Wollaston, V., Fryer, Michael J, Morison, James I.L., Buchanan-Wollaston, Vicky, Sparrow, Penelope AC, Baker, N.R., Baker, Neil R., Hickman, R., Martin, C., Albihlal, Waleed S., Morison, James I. L., Richard, François, Ott, Sascha, Morison, James IL, Fryer, M.J., Lawson, T., Beynon, J.L.   +46 more
core   +1 more source