Results 101 to 110 of about 15,365,257 (385)

Nucleosome-mediated cooperativity between transcription factors [PDF]

, 2009
Cooperative binding of transcription factors (TFs) to cis-regulatory regions (CRRs) is essential for precision of gene expression in development and other processes.
Adams, Anderson, Arnosti, Arnosti, Berman, Bintu, Changeux, Chen, Dion, Gao, Hare, Ioshikhes, Ioshikhes, Iyer, John, Kaplan, Kim, L. A. Mirny, Lam, Lee, Lee, Li, Li, Li, Lin, Maerkl, Mavrich, Miller, Monod, Morse, Moses, Oliviero, Panne, Pettersson, Phair, Poirier, Polach, Polach, Ransom, Sabo, Saiz, Segal, Sinha, Tillo, Trifonov, Vashee, Weinberg, Wunderlich, Xu, Zhang   +49 more
core   +4 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Predicting variation of DNA shape preferences in protein-DNA interaction in cancer cells with a new biophysical model

, 2017
DNA shape readout is an important mechanism of target site recognition by transcription factors, in addition to the sequence readout. Several models of transcription factor-DNA binding which consider DNA shape have been developed in recent years.
Batmanov, Kirill, Wang, Junbai
core   +2 more sources

Melatonin Alters Age-Related Changes in Transcription Factors and Kinase Activation [PDF]

, 2010
Male mice were fed 40 ppm melatonin for 2 months prior to sacrifice at age 26 months, and compared with both 26 and 4 month-old untreated controls. The nuclear translocation of NF-κB increased with age in both brain and spleen and this was reversed by ...
A Jagota, B Caballero, BP Rutten, CE Finch, D Lahiri, Debomoy K. Lahiri, DK Lahiri, E Head, E Sharman, EH Sharman, G Mayer, H Li, Huihui Li, Jason A. Bailey, JL Teeling, Jun Zhou, KG Sharman, KG Sharman, L Yang, M Griffiths, M Li, M Sánchez-Hidalgo, Meixia Wu, NL Sparkman, P Lemoine, R Sandhir, RH Waterston, S Denis-Donini, S Kaewsuk, SC Bondy, Stephen C. Bondy, V Vukic, VM Perreau, Y Marchalant, Y Uyanikgil, YH Wu   +35 more
core   +4 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Transcription factor DREF regulates expression of the microRNA gene bantam in Drosophila melanogaster

Вавиловский журнал генетики и селекции
The bantam gene encodes a vital microRNA and has a complex expression pattern in various tissues at different stages of Drosophila development. This microRNA is involved in the control of normal development of the ocu lar and wing imaginal discs, the ...
M. B.  Schwartz, M. M. Prudnikova, O. V. Andreenkov, E. I. Volkova, I. F. Zhimulev, O. V. Antonenko, S.  A. Demakov   +6 more
doaj   +1 more source

Targeting Transcription Factors for Cancer Treatment

Molecules, 2018
Transcription factors are involved in a large number of human diseases such as cancers for which they account for about 20% of all oncogenes identified so far. For long time, with the exception of ligand-inducible nuclear receptors, transcription factors
M. Lambert, S. Jambon, S. Depauw, M. David-Cordonnier   +3 more
semanticscholar   +1 more source

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas [PDF]

, 2000
Differentiation of early gut endoderm cells into the endocrine cells forming the pancreatic islets of Langerhans depends on a cascade of gene activation events controlled by transcription factors including the basic helix-loop-helix (bHLH) proteins.
Anderson, David J., Conners, Jennifer R., German, Michael S., Johnson, Jeffrey D., Kalamaras, Julie, Lee, Jacqueline E., Scheel, David W., Schwitzgebel, Valérie M., Sussel, Lori   +8 more
core  

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells. [PDF]

, 2017
Endothelial cells (ECs) are critical determinants of vascular homeostasis and inflammation, but transcriptional mechanisms specifying their identities and functional states remain poorly understood.
Glass, Christopher K, Hadeli, Nizar K, Hogan, Nicholas T, Lam, Michael T, Romanoski, Casey E, Springstead, James R, Stolze, Lindsey K, Whalen, Michael B   +7 more
core   +2 more sources