Results 141 to 150 of about 2,461,635 (330)

Transcriptional regulation of suberin and its response to the environment

Xibei zhiwu xuebao
[Objective] Suberin is a polyester type biopolymer that specifically deposits in tissues such as the endodermis, periderm, seed coat, and wound epidermis of plants.
ZHOU Yue, AN Yongping, MA Rong, WANG Pei
doaj   +1 more source

Networks of WRKY transcription factors in defense signaling [PDF]

, 2007
Eulgem, T., Somssich, I.
core   +2 more sources

Two different liver-specific factors stimulate in vitro transcription from the human alpha 1-antitrypsin promoter. [PDF]

, 1988
Paolo Monaci, Alfredo Nicosia, R. Cortese   +2 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Ubiquitous MEIS transcription factors actuate lineage-specific transcription to establish cell fate

The EMBO Journal
Control of gene expression is commonly mediated by distinct combinations of transcription factors (TFs). This cooperative action allows the integration of multiple biological signals at regulatory elements, resulting in highly specific gene expression ...
Zoulfia Darieva, Peyman Zarrineh, Naomi Phillips, Joshua Mallen, Araceli Garcia Mora, Ian Donaldson, Laure Bridoux, Megan Douglas, Sara F Dias Henriques, Dorothea Schulte, Matthew J Birket, Nicoletta Bobola   +11 more
doaj   +1 more source

GATA-4 and GATA-5 Transcription Factor Genes and Potential Downstream Antitumor Target Genes Are Epigenetically Silenced in Colorectal and Gastric Cancer

, 2003
Yoshimitsu Akiyama, Neil Watkins, Hiromu Suzuki, Kam-Wing Jair, Manon van Engeland, Manel Esteller, H Sakai, Chun-Yan Ren, Yasuhito Yuasa, James G. Herman, Stephen B. Baylin   +10 more
openalex   +1 more source

Expression and Splice Variant Analysis of Human TCF4 Transcription Factor in Esophageal Cancer [PDF]

, 2015
Gang He, Xingying Guan, Xuedan Chen, Yan Wang, Chao Luo, Bo Zhang   +5 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Gene Expression of Basic Helix-Loop-Helix Transcription Factor, SHARP-2, Is Regulated by Gonadotropins in the Rat Ovary and MA-10 Cells1 [PDF]

, 2004
Kazuya Yamada, Hiroko Kawata, Tetsuya Mizutani, Takeshi Arima, Takashi Yazawa, Kaoru Matsuura, Zhangfei Shou, Toshio Sekiguchi, Miki Yoshino, Takashi Kajitani, Kaoru Miyamoto   +10 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source