Results 211 to 220 of about 2,461,635 (330)

Unraveling the multifaceted roles of SPL transcription factors in leaf development. [PDF]

Front Plant Sci
Ritonga FN, Xu Y, Cui B, Liu X, Gao J, Li J.   +5 more
europepmc   +1 more source

Single-molecule quantification of lipotoxic expression of activating transcription factor 3

, 2014
Idir Yahiatène, Hnin Hnin Aung, Dennis W. Wilson, John C. Rutledge   +3 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

E2F transcription factors as multimodal biomarkers for pan-cancer management. [PDF]

Sci Rep
Yang S, Li K, Suo Y, Zhang Z, Chen H, Lin Y, Fu C, Qie Y, Shen C, Hu H.   +9 more
europepmc   +1 more source

Prediction of transcription factor bindings sites affected by SNPs located at the osteopontin promoter

, 2017
Marco A. Briones‐Orta, S. Eréndira Avendaño‐Vázquez, Diana I. Aparicio‐Bautista, Jason D. Coombes, Georg F. Weber, Wing‐Kin Syn   +5 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Transcriptomics informed discovery of developmentally essential transcription factors. [PDF]

Biol Open
Forbes G, Schaap P.
europepmc   +1 more source

Abstract 3662: Plasticity of transcriptional and epigenetic cellular states in neuroblastoma is driven by core lineage transcription factors

, 2019
Johan van Nes, Tim van Groningen, Linda J. Valentijn, Danny A. Zwijnenburg, Ellen M. Westerhout, Mohamed Hamdi, Jan Köster, Rogier Versteeg   +7 more
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Expanding the toolbox to develop IAP-based degraders of TEAD transcription factors. [PDF]

Commun Chem
Gupta N, Trainor N, Radwan M, Nguyen S, Duncan L, Tang AX, Beveridge J, Silke N, Yousef J, Bilgilier C, Wachter J, Greb P, Jandova Z, Eliaš J, Kopf S, Gerstberger T, Stolt-Bergner P, Braun N, Weinstabl H, McConnell DB, Mauri F, Lucet IS, Silke J, Chessum NEA, Roy MJ.   +24 more
europepmc   +1 more source