Results 211 to 220 of about 15,365,257 (385)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Identification and analysis of key transcription factors in esophageal squamous cell carcinoma. [PDF]

Discov Oncol
Chen ZR, Cheng ZY, Zhou SW, Zhang YH, Gao Y, Yu CT, Tian B, Zhang X, Bian Y, Hao MJ, Wang W, Xin L, Lin H, Wang LW.   +13 more
europepmc   +1 more source

The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex. [PDF]

, 1989
Miller Huang, Patrick Hearing
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Transcription Factors and Methods for the Pharmacological Correction of Their Activity. [PDF]

Int J Mol Sci
Guryanova SV, Maksimova TV, Azova MM.
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Disease-linked regulatory DNA variants and homeostatic transcription factors in epidermis. [PDF]

Nat Commun
Porter DF, Meyers RM, Miao W, Reynolds DL, Hong AW, Yang X, Srinivasan S, Mondal S, Siprashvili Z, Fabo T, Zhou R, Nguyen T, Ducoli L, Meyers JM, Nguyen DT, Ko LA, Kellman LN, Elfaki I, Guo M, Winge MC, Jackrazi LV, Lopez-Pajares V, Liu BB, Qu Y, Porter IE, Kim SH, Kim G, Tao S, Engreitz JM, Khavari PA.   +29 more
europepmc   +1 more source

Regulation of expression and activity of the yeast transcription factor ADR1. [PDF]

, 1988
Hal Blumberg, Toinette Hartshorne, E T Young   +2 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Regulatory Network of Transcription Factors in Macrophage Polarization. [PDF]

Immunotargets Ther
Liu J, Wang M, Zhao Y.
europepmc   +1 more source