Results 241 to 250 of about 15,584,477 (336)

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Disease-linked regulatory DNA variants and homeostatic transcription factors in epidermis. [PDF]

Nat Commun
Porter DF, Meyers RM, Miao W, Reynolds DL, Hong AW, Yang X, Srinivasan S, Mondal S, Siprashvili Z, Fabo T, Zhou R, Nguyen T, Ducoli L, Meyers JM, Nguyen DT, Ko LA, Kellman LN, Elfaki I, Guo M, Winge MC, Jackrazi LV, Lopez-Pajares V, Liu BB, Qu Y, Porter IE, Kim SH, Kim G, Tao S, Engreitz JM, Khavari PA.   +29 more
europepmc   +1 more source

Genome-Wide Analysis of Ethylene-Responsive Element Binding Factor-Associated Amphiphilic Repression Motif-Containing Transcriptional Regulators in Arabidopsis [PDF]

, 2010
Sateesh Kagale, Matthew G. Links, Kevin Rozwadowski   +2 more
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

From Transcription Factors Dysregulation to Malignancy: In Silico Reconstruction of Cancer's Foundational Drivers-The Eternity Triangle. [PDF]

Int J Mol Sci
Cammarota AL, Carrizzo A, De Marco M, Bukvic N, Romano FJ, Rosati A, Chetta M.   +6 more
europepmc   +1 more source

Transcriptional Regulation centered on TATA box-binding factor TFIID

, 1995
Masami Horikoshi
openalex   +1 more source

Critical Roles for Transcription Factor GATA-3 in Thymocyte Development [PDF]

, 2003
Sung‐Yun Pai, Morgan Truitt, Chao-Nan Ting, Jeffrey M. Leiden, Laurie H. Glimcher, I‐Cheng Ho   +5 more
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

The Regulatory Network of Transcription Factors in Macrophage Polarization. [PDF]

Immunotargets Ther
Liu J, Wang M, Zhao Y.
europepmc   +1 more source

Human Naive CD8 T Cells Down-Regulate Expression of the WNT Pathway Transcription Factors Lymphoid Enhancer Binding Factor 1 and Transcription Factor 7 (T Cell Factor-1) following Antigen Encounter In Vitro and In Vivo [PDF]

, 2006
Tim Willinger, Tom C. Freeman, Mark Herbert, Hitoshi Hasegawa, Andrew J. McMichael, Margaret Callan   +5 more
openalex   +1 more source