Results 281 to 290 of about 15,584,477 (336)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A memory transcriptome time course reveals essential long-term memory transcription factors. [PDF]

Nat Commun
Jones SG, Gil-Martí B, Sacristán-Horcajada E, Edison AC, Butler EF, Miandashti N, Roselli C, Turiégano E, Boto T, Kramer JM, Martin FA.   +10 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Overexpression of cotton PLATZ transcription factors GhPLATZ01 and GhPLATZ15 improves the drought resistance of tomato. [PDF]

BMC Plant Biol
Liu T, Xue Y, Ding X, Zhang Y, Li Z, Zhang Z, Yang Z, Zhu J, Liu R.   +8 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Identification of NAC Transcription Factors Associated with Leaf Senescence in <i>Clerodendrum japonicum</i>. [PDF]

Int J Mol Sci
Wang C, Liao G, Duan Y, Su L, He C, Xu M, Wang H.   +6 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Genome-wide identification, phylogenetic analysis and expression pattern study of trihelix transcription factors in Pisum sativum L. [PDF]

Sci Rep
Wu X, Zhu Z, Chen Z, Xie X, Liu Z, Zhang L.   +5 more
europepmc   +1 more source

Mutation of a bHLH transcription factor allowed almond domestication

, 2019
Raquel Sánchez‐Pérez, Stefano Pavan, Rosa Mazzeo, Claudiu MOLDOVAN, Riccardo Aiese Cigliano, Jorge Del Cueto, Francesca Ricciardi, Concetta Lotti, Luigi M. Ricciardi, F. Dicenta, Rosa L. López‐Marqués, Birger Lindberg Møller   +11 more
openalex   +2 more sources

Genomic footprinting reveals cell-type-specific binding of ubiquitous transcription factors [PDF]

, 1987
Becker, Peter B., Ruppert, Siegfried, Schütz, Günther   +2 more
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