Results 341 to 350 of about 15,143,293 (401)
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Transcription factors of the NFAT family: regulation and function.
Annual Review of Immunology, 1997As targets for the immunosuppressive drugs cyclosporin A and FK506, transcription factors of the NFAT (nuclear factor of activated T cells) family have been the focus of much attention. NFAT proteins, which are expressed in most immune-system cells, play
A. Rao, C. Luo, P. Hogan
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Transcription factors in autoimmunity
Current Opinion in Immunology, 2003The identification of two transcription factors that, when mutated, are responsible for severe autoimmune disease in humans is leading to a better understanding of the fundamental processes involved in T-cell tolerance. Both AIRE and FOXP3, identified initially via their association with genetically manipulated mice, are critically involved in ...
Steven F. Ziegler, Fred Ramsdell
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Transcription factor complexes
Current Opinion in Structural Biology, 2002Considerable progress has been made during the past year on structural studies of the eukaryotic and bacterial transcription factors that control RNA polymerase function via the formation of multiprotein complexes on promoter DNA. Recently determined structures include negative cofactor 2 recognizing a preformed TATA-box-binding protein-DNA binary ...
Stephen K. Burley, Katsuhiko Kamada
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Transcription factors on the move
Current Opinion in Plant Biology, 2012Mobile transcription factors play essential roles in plant development including the control of cell identity and tissue patterning, as well as organ initiation and the induction of major developmental switches. Within the past few years, the molecules and cellular structures that regulate the movement of these signals have emerged.
Kimberly L. Gallagher, Shuang Wu
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Transcription factors: An overview
The International Journal of Biochemistry & Cell Biology, 1997This special issue of the International Journal of Biochemistry and Cell Biology contains a series of review articles and original papers dealing with the topic of transcription factors. The purpose of this introductory article is to provide an overview of these factors, their mechanism of action, their regulation and the manner in which alterations in
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Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
Science, 2000The completion of the Arabidopsis thaliana genome sequence allows a comparative analysis of transcriptional regulators across the three eukaryotic kingdoms.
J. Riechmann +16 more
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Transcription Factors and Hypopituitarism
Trends in Endocrinology & Metabolism, 1999Several homeodomain factors are found in the developing anterior pituitary lobe. The production of these developmental transcription factors has distinct temporal and spatial patterns. By interacting with each other, as well as with other extrinsic and intrinsic signals, they control cell determination and specification.
Sally Radovick +2 more
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2002
Publisher Summary Asthma and chronic obstructive pulmonary disease (COPD) are characterized by an increased expression of the components of the inflammatory cascade. Inflammation is the central feature of both the diseases as both involve the recruitment and activation of inflammatory cells and changes in the structural cells of the lung.
Ian M. Adcock, Gaetano Caramori
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Publisher Summary Asthma and chronic obstructive pulmonary disease (COPD) are characterized by an increased expression of the components of the inflammatory cascade. Inflammation is the central feature of both the diseases as both involve the recruitment and activation of inflammatory cells and changes in the structural cells of the lung.
Ian M. Adcock, Gaetano Caramori
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Transcription factors and osteoblasts
Frontiers in Bioscience, 1998Transcription factors play a key role in determination of the fate of the cells in osteoblastic and chondrocytic lineage. A runt family member, Cbfa, is indispensable for osteoblastic differentiation. Sox 9 and scleraxis are involved in the phenotypic expression in chondrocytes and the cells of early stage connective tissues.
M, Noda +7 more
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TRANSCRIPTION FACTORS | Overview
2006The term ‘transcription factor’ refers to a large family of proteins, which exert transcriptional control via specific interactions with regulatory gene sequences. Here, we provide a summary of the different classes of the transcription factor divided according to their DNA-binding motifs. The modular structure of transcription factors and the presence
Adcock I. M., Ito K., CARAMORI, Gaetano
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