Results 91 to 100 of about 4,117,946 (252)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Regulation of transcription by R loop-nucleated transcription condensate assembly

Cell & Bioscience
Prevalence of promoter paused R loops formed from frequent RNA PolII pausing in eukaryotic cells not only pose a significant threat to genomic stability, but also a potent regulator of transcription.
Raissa Regina Ng, Zhongyang Lin, Heng Wee Tan, Yan-Ming Xu, Andy T. Y. Lau   +4 more
doaj   +1 more source

Overcoming chromatin barriers

eLife, 2019
Single-molecule experiments reveal the dynamics of transcription through a nucleosome with single-base-pair accuracy.
Babette E de Jong, John van Noort
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Temporal regulation of murine cytomegalovirus transcription and mapping of viral RNA synthesized at immediate early times after infection [PDF]

, 1984
The replication of murine cytomegalovirus strain Smith in murine embryonic fibroblasts was investigated at immediate early, early, and late times after infection.
Koszinowski, Ulrich H., Ebeling-Keil, Angelika, Keil, Günther M.   +2 more
core   +1 more source

Transcription factor DREF regulates expression of the microRNA gene bantam in Drosophila melanogaster

Вавиловский журнал генетики и селекции
The bantam gene encodes a vital microRNA and has a complex expression pattern in various tissues at different stages of Drosophila development. This microRNA is involved in the control of normal development of the ocu lar and wing imaginal discs, the ...
M. B.  Schwartz, M. M. Prudnikova, O. V. Andreenkov, E. I. Volkova, I. F. Zhimulev, O. V. Antonenko, S.  A. Demakov   +6 more
doaj   +1 more source

The structure of the core NuRD repression complex provides insights into its interaction with chromatin

eLife, 2016
The NuRD complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodelling activities. The complex regulates the higher-order structure of chromatin, and has important roles in the regulation ...
Christopher J Millard, Niranjan Varma, Almutasem Saleh, Kyle Morris, Peter J Watson, Andrew R Bottrill, Louise Fairall, Corinne J Smith, John WR Schwabe   +8 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Regulation of heat shock-responsive gene transcription by RNF20/40-mediated eEF1BδLmonoubiquitylation

, 2019
RNF20/40 E3 ubiquitin ligase-mediated histone H2B monoubiquitylation plays important roles in many cellular processes, including transcriptional regulation.
Kim, Jaehoon
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source