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Structural basis of Integrator-mediated transcription regulation
Science, 2021Description How Integrator ends transcription early Transcription is the central process that activates the genetic information in cells, but our understanding of how gene transcription is regulated is incomplete.
Isaac Fianu +6 more
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Transcriptional Regulation and Pharmacogenomics [PDF]
Pharmacogenomics, 2011 Interindividual variable drug response is correlated with sequence alterations in genes encoding drug-metabolizing enzymes and transporters, affecting drug absorption, distribution, metabolism and excretion. This variable drug response may have an impact on disease therapeutic outcomes, tolerance to adverse drug reactions and even survival.
Georgitsi, Marianthi +3 more
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Actin in transcription and transcription regulation
Current Opinion in Cell Biology, 2006Recent research has provided convincing evidence that actin plays several important roles in gene transcription. First, actin can bind transcription factors and determine their subcellular localization. Second, actin is a component of chromatin remodeling complexes involved in transcriptional activation.
Francesc Miralles, Neus Visa
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CTCF: a Swiss-army knife for genome organization and transcription regulation.
Essays in Biochemistry, 2019Orchestrating vertebrate genomes require a complex interplay between the linear composition of the genome and its 3D organization inside the nucleus. This requires the function of specialized proteins, able to tune various aspects of genome organization ...
L. Braccioli, Elzo de Wit
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Transcriptional regulation and metabolism
Biochemical Society Transactions, 2005Understanding organisms from a systems perspective is essential for predicting cellular behaviour as well as designing gene-metabolic circuits for novel functions. The structure, dynamics and interactions of cellular networks are all vital components of systems biology.
Mark P. Brynildsen +2 more
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Transcriptional Regulation of Adipogenesis
Comprehensive Physiology, 2017ABSTRACTAdipocytes are the defining cell type of adipose tissue. Once considered a passive participant in energy storage, adipose tissue is now recognized as a dynamic organ that contributes to several important physiological processes, such as lipid metabolism, systemic energy homeostasis, and whole‐body insulin sensitivity.
Jacqueline M. Stephens +3 more
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Transcription Regulation in Spermatogenesis
2009Spermatogenesis is a highly coordinated process in which diploid spermatogonia (2n) differentiate into mature haploid (1n) spermatozoa in the seminiferous epithelium. In this process, spermatogonia undergo several mitotic divisions and either enter a stem cell renewal pathway, or commit themsevles for further development.
Lui, WY, Cheng, CY
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Mediator of transcriptional regulation
Trends in Biochemical Sciences, 1996A multi-protein complex, termed mediator, has been isolated from yeast, based on its requirement for transcriptional activation in a system reconstituted from pure RNA polymerase II and general transcription factors. Mediator polypeptides include the products of many genes previously recovered from screens for mutations affecting transcription.
Young Joon Kim, Stefan Björklund
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Transcriptional regulation of hemopoiesis
Developmental & Comparative Immunology, 2001The regulation of blood cell formation, or hemopoiesis, is central to the replenishment of mature effector cells of innate and acquired immune responses. These cells fulfil specific roles in the host defense against invading pathogens, and in the maintenance of homeostasis.
Daniel R. Barreda, Miodrag Belosevic
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