Results 351 to 360 of about 5,538,535 (384)
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Transcriptional regulation by cAMP
Current Biology, 1991Cyclic AMP regulates a myriad of cellular processes through the cAMP-dependent protein kinase A. In many cases, activation of protein kinase A leads to altered patterns of gene transcription. Identification of the cAMP-response-element-binding-protein as a major nuclear substrate for protein kinase A accounts for many recent advances in understanding ...
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Transcriptional Regulation of Metabolism
Physiological Reviews, 2006Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made towards elucidating the mechanisms controlling the major regulatory pathways are now being rewarded. At the molecular level, the crucial role of transcription factors is particularly well-illustrated by the link between alterations of their functions and the ...
Liliane Michalik +2 more
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Chromatin and transcription regulation
Molecular Biology, 2007Recent years are marked by drastic increase of interest in the role of chromatin in regulation of gene activity. In the seventies of the last century many studies were undertaken in order to identify different forms of histones involved in regulation on transcription. The results of these studies were conflicting. Determination of primary structures of
Sergey V. Razin, Sergey V. Razin
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Transcriptional regulation of BRCA1 [PDF]
, 1999 Abstract : Germline mutations in BRCAl lead to an increased risk of breast and ovarian cancer, with loss of the second, normal allele critical to tumorigenesis. It was widely presumed that the cloning and characterization of genes involved in hereditary breast cancer would lead to a better understanding of the genesis of the more common non-inherited ...
Shannon R. Payne, Mary C. King
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Transcriptional Regulation of Myelopoiesis
International Journal of Hematology, 2002A common myeloid progenitor gives rise to both granulocytes and monocytes. The early stages of granulopoiesis are mediated by the C/EBPalpha, PU.1, RAR, CBF, and c-Myb transcription factors, and the later stages require C/EBPepsilon, PU.1, and CDP. Monocyte development requires PU.1 and interferon consensus sequence binding protein and can be induced ...
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Mechanogenetic regulation of transcription
Biochimie, 1991In many biological systems mechanical forces regulate gene expression: in bacteria changes in turgor pressure cause a deformation of the membrane and induce the expression of osmoregulatory genes; in plants gravity regulates cell growth ('geotropism'); in mammals stretching a muscle induces hypertrophy which is accompanied by qualitative changes in ...
L. Rappaport +2 more
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Transcriptional regulation of ADAMTS13
Thrombosis and Haemostasis, 2005SummaryThe metalloproteinase ADAMTS13 cleaves VWF multimers instantaneously when they are released from endothelial cells. Absent or manifestly diminished proteolytic activity of ADAMTS13 results in the appearance and accumulation of ultralarge VWF multimers (ULVWFM) in plasma, characterised by the manifestation of Thrombotic Thrombocytopenic Purpura ...
Claus, Ralf A. +7 more
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BRCA1 regulation of transcription
Cancer Letters, 2006BRCA1, a tumor suppressor gene on chromosome 17q21, was identified in 1994 based on its linkage to hereditary breast and ovarian cancer syndromes. The BRCA1 gene encodes a 220 kDa nuclear phosphoprotein. Studies aimed at elucidating the mechanisms of its tumor suppressor activity have revealed, in part, that BRCA1 participates in the DNA damage ...
Yongxian Ma, Saijun Fan, Eliot M. Rosen
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Mechanical regulation of chromatin and transcription
Nature reviews genetics, 2022S. Dupont, S. Wickström
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DnaA as a Transcription Regulator
2003Publisher Summary This chapter reviews that DnaA is a transcription factor involved in the regulation of several E. Coli genes. DnaA can act as a repressor or it can be a transcriptional activator. DnaA might terminate transcription, provided two suitably located DnaA boxes mediate loop formation of the template.
Christoph Weigel, Walter Messer
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