E2F7 promotes ESCC progression and cisplatin resistance through transcriptional activation of DVL3 and the Wnt signaling pathway. [PDF]
Li X, Chen L, Xu T, Yan Z.
europepmc +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
ELK4 Promotes Vasculogenic Mimicry in Oral Squamous Cell Carcinoma via Driving <i>DHFR</i> Transcriptional Activation. [PDF]
Qiu Y +7 more
europepmc +1 more source
Transcriptional activation of MACF1 by NR2F1 drives WNT-mediated focal adhesion and metastasis in lung adenocarcinoma. [PDF]
Zhou Y, Wang J, Sun Y, Zhang Q, Su X.
europepmc +1 more source
Myocyte enhancer factor 2A orchestrates vascular redox homeostasis via direct transcriptional activation of SIRT1. [PDF]
Liu B +8 more
europepmc +1 more source
<i>ZNF460</i> Promotes <i>GSDME</i>-Driven Pyroptosis via <i>PKM2</i> Transcriptional Activation in Aortic Dissection. [PDF]
Yang Q +8 more
europepmc +1 more source
m6A methylation-modified ETV1 drives multiple myeloma progression and M2 polarization of tumor-associated macrophage through transcriptional activation of RBMS1. [PDF]
Liu Y +6 more
europepmc +1 more source
PLK1 stabilizes β-catenin to drive colorectal carcinogenesis through NFKB2-mediated transcriptional activation of USP2a and site-specific phosphorylation. [PDF]
Li Y +10 more
europepmc +1 more source
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Current Opinion in Cell Biology, 1999Studies from the past several years have revealed that adipogenesis is controlled by an interplay of transcription factors, including members of the CCAAT/enhancer binding protein family and peroxisome proliferator activated receptor gamma. In addition to providing a new understanding of this aspect of the energy balance systems, these factors provide ...
Z, Wu, P, Puigserver, B M, Spiegelman
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Transcriptional activation by recruitment
Nature, 1997The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating regions and their targets, and for the
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