Results 231 to 240 of about 2,492,980 (260)

Tanshinone IIA inhibits epithelial-mesenchymal transition in ovarian cancer by promoting NR3C2 transcriptional activation of ING1. [PDF]

iScience
Wang X, Zhang D, Wang T, Li X, Zhang J.
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Hepatocyte TonEBP promotes metabolic stress-induced hepatic fibroinflammation involving transcriptional activation of ELR⁺ CXC chemokines. [PDF]

Cell Death Discov
Lee JH, Song H, Yoo EJ, Jeong Y, Ko SM, Shin GW, Choi GE, Jee Y, Kang M, Yang J, Hur SP, Park JE, Lee Y, Park HK, Yun JH, Jang MK, Lee-Kwon W, Kwon HM, Choi SY.   +18 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

HOXB4 Promotes Bladder Cancer Progression in Part Through Transcriptional Activation of Smoothened. [PDF]

FASEB J
Jin Z, Yang W, Peng Y, Ma L, Li Z, Dong J, Ji Z.   +6 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Transcriptional Activation of Estrogen Receptor-Alpha and Estrogen Receptor-Beta from Elephant Shark (<i>Callorhynchus milii</i>). [PDF]

Genes (Basel)
Ao Y, Narita H, Takagi W, Hyodo S, Baker ME, Katsu Y.   +5 more
europepmc   +1 more source

Transcriptional activation of PPP1R14C by KLF7 unleashes CDK1 activity to promote lung squamous cell carcinoma. [PDF]

Sci Rep
Xing L, Yuan C, Shen X, Xiao K.
europepmc   +1 more source

HOXA9 orchestrates EMT and metastasis in oral cancer via transcriptional activation of vimentin and β-catenin signaling. [PDF]

Cell Death Dis
Shenoy US, Adiga D, Basavarajappa DS, Kumar NAN, Kudva A, Kunnumakkara AB, Hunter KD, Kabekkodu SP, Radhakrishnan R.   +8 more
europepmc   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation. [PDF]

FEBS J
Zhang R, Ahmadian S, Piepers J, Bock F, Keulers T, Vooijs MA.   +5 more
europepmc   +1 more source