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The Second Paradigm for Activation of Transcription
2005Publisher Summary Gene transcription is central to the development, differentiation, and adaptation of cells. Control of transcription requires the interplay of signaling pathways with the molecular machinery of transcription, the DNA-dependent RNA polymerase (RNAP) enzyme, regulatory proteins that act upon it, and the nucleic acid that is ...
S R, Wigneshweraraj +8 more
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Transcriptional activation by nuclear receptors
Essays in Biochemistry, 2004Transcriptional activation by nuclear receptors (NRs) involves the recruitment of distinct classes of co-activators and other transcription-related factors to target promoters in the chromatin environment of the nucleus. Chromatin has a general repressive effect on transcription, but also provides opportunities for NRs to regulate transcription by ...
Mari Luz, Acevedo, W Lee, Kraus
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Transcription Activation by Nuclear Receptors
Journal of Receptor Research, 1993Nuclear receptors constitute a superfamily of ligand-inducible transcription factors which respond to endocrine, paracrine and, possibly, autocrine signals. Multiple regulatory mechanisms assure that signal transduction results in an accurate regulation of the respective gene networks.
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Assays for Transcription Factor Activity
2003Transcription factors interact at promoters to modulate the transcription of genes. This chapter describes three in vitro methods that can be used to monitor their activity: transcript assays, abortive initiation assays, and potassium permanganate footprinting.
V, Rhodius, N, Savery, A, Kolb, S, Busby
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Redox regulation of transcriptional activators
Free Radical Biology and Medicine, 1996Transcription factors/activators are a group of proteins that bind to specific consensus sequences (cis elements) in the promoter regions of downstream target/effector genes and transactivate or repress effector gene expression. The up- or downregulation of effector genes will ultimately lead to many biological changes such as proliferation, growth ...
Y, Sun, L W, Oberley
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Transcriptional Activation by the Myc Oncoprotein
2006The Myc transcription factor functions as a downstream effector of most mitogenic signals. Myc is synthesized rapidly in response to extracellular mitogenic signals, and blocking Myc induction abolishes or at least severely attenuates any mitogenic response.
M D, Cole, M A, Nikiforov
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The Enigma of Transcriptional Activation Domains
Journal of Molecular BiologyActivation domains (ADs) of eukaryotic gene activators remain enigmatic for decades as short, extremely variable sequences which often are intrinsically disordered in structure and interact with an uncertain number of targets. The general absence of specificity increasingly complicates the utilization of the widely accepted mechanism of AD function by ...
Alexandre M, Erkine +2 more
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Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation
Molecular Cell, 2021Joo-Hyung Lee +2 more
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