Results 101 to 110 of about 962,811 (315)

A steady state model for the transcriptional regulation of filamentous growth in Saccharomyces cerevisiae

, 2008
Occurrence of multiple Upstream Activation Sites (UASs) is a structural motif that is observed within the promoter of eukaryotic genes for coordinating gene expression.
Vinod, Palakkad Krishnan Unni, Venkatesh, Kareenhalli V.   +1 more
core   +1 more source

PIM1-dependent phosphorylation of Histone H3 at Serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.

, 2007
The serine/threonine kinase PIM1, cooperates with MYC in cell cycle progression and tumorigenesis. However, the nature of this cooperation remains elusive.
Salvatore Oliviero, Serafini, Riccardo, Riccardo Serafini, Alessandra De Robertis, Alessio Zippo, De Robertis, Alessandra, Zippo, Alessio, Oliviero, Salvatore   +7 more
core   +1 more source

Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease [PDF]

, 2013
Background: Tobacco is a leading environmental factor in the initiation of respiratory diseases and causes chronic obstructive pulmonary disease (COPD).
Groneberg, David A., David A Groneberg, Fischer, Axel, Frank R Scholz, Springer, Jochen, Jochen Springer, Groneberg, Jan David Alexander, Christian Peiser, Scholz, Frank R., Axel Fischer, Peiser, Christian, Q Dinh, Quarcoo, David, David Quarcoo, Dinh, Q. Thai   +14 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Mechanism of PAX3-FKHR in transcriptional regulation

, 2009
[[abstract]]The PAX3-FKHR fusion protein is formed as a result of t(2;13) chromosomal translocations and functions as a transcription factor to activate transcription.
Ching-Yi Lin
core  

The dual transcriptional regulator CysR in Corynebacterium glutamicum ATCC 13032 controls a subset of genes of the McbR regulon in response to the availability of sulphide acceptor molecules

, 2008
Rückert C, Milse J, Albersmeier A, Koch DJ, Pühler A, Kalinowski J. The dual transcriptional regulator CysR in Corynebacterium glutamicum ATCC 13032 controls a subset of genes of the McbR regulon in response to the availability of sulphide acceptor ...
Rückert, Christian ; https://orcid.org/, Daniel J Koch, Johanna Milse, Koch, Daniel J., Albersmeier, Andreas, Christian Rückert, Pühler, Alfred ; https://orcid.org/, Kalinowski, Jörn, Alfred Pühler, Andreas Albersmeier, Milse, Johanna, Jörn Kalinowski   +11 more
core   +1 more source

Estrogen-related receptor α (ERRα) : a novel target in type 2 diabetes [PDF]

, 2005
Recent studies have shown that reduced mitochondrial content and function in skeletal muscle are common features of type 2 diabetes. Here, we review the molecular mechanisms involved in the regulation of mitochondrial genes in skeletal muscle, focusing ...
Handschin, C., Mootha, V. K.
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Regulation of hepatic heme synthesis by drugs, bile acids and nutrition : a transcriptional network regulating [delta]-aminolevulinic acid synthase 1 (ALAS1) [PDF]

, 2008
ALAS1 is the rate limiting enzyme of heme synthesis. It is highly inducible in liver in cases of increased heme demand, such as drug metabolism or in inducible hepatic porphyrias.
Peyer, Anne-Kathrin
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source