Results 81 to 90 of about 3,231,478 (258)
Journal of Obesity, 2017 Fat mass and obesity-associated (FTO) gene influences obesity but studies have shown that environmental/lifestyle variables like physical activity (PA), time spent sitting (TSS), and energy intake might mediate the effect.
Bolaji Fatai Oyeyemi +3 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Transcriptional regulation of the operon encoding stress-responsive ECF sigma factor SigH and its anti-sigma factor RshA, and control of its regulatory network in Corynebacterium glutamicum [PDF]
, 2012 Busche T, Silar R, Picmanova M, Patek M, Kalinowski J. Transcriptional regulation of the operon encoding stress-responsive ECF sigma factor SigH and its anti-sigma factor RshA, and control of its regulatory network in Corynebacterium glutamicum.
Miroslav Pátek +14 more
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Regulation of skeletal muscle plasticity by the transcriptional coregulators PGC-1α and NCoR1 [PDF]
, 2013 Skeletal muscle plasticity is regulated by a wide range of factors, among which environmental stimuli such as exercise play a central role. Importantly, changes in skeletal muscle phenotype exert a direct impact on health and risk to premature death.
Pérez-Schindler, Joaquín
core +1 more source
, 2008 Occurrence of multiple Upstream Activation Sites (UASs) is a structural motif that is observed within the promoter of eukaryotic genes for coordinating gene expression.
Vinod, Palakkad Krishnan Unni +1 more
core +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Post-transcriptional regulation in the developing embryo
, 2019 Embryonic development is critically reliant on well-defined spatial and temporal patterns of gene expression. These patterns are often achieved through the regulation of gene expression at the mRNA level.
Fernandes, Sara Maria Ferreira
core
Electricity network regulation in the EU : The challenges ahead for transmission and distribution
, 2018 The UK model of incentive regulation of power grids was at one time the most advanced, and elements of it were adopted throughout the EU. This model worked well, particularly in the context of limited investment and innovation, a single and strong ...
core +1 more source
Discovering transcriptional modules by Bayesian data integration [PDF]
, 2010 Motivation: We present a method for directly inferring transcriptional modules (TMs) by integrating gene expression and transcription factor binding (ChIP-chip) data.
Richard S. Savage +15 more
core +1 more source