Results 81 to 90 of about 2,483,359 (253)

Regulation of Transcription of Coronaviruses [PDF]

, 1995
To study factors involved in regulation of transcription of coronaviruses, we constructed defective interfering (DI) RNAs containing sg RNA promoters at multiple positions. Analysis of the amounts of sg DI RNA produced by these DIs resulted in the following observations: (i) a downstream promoter downregulates an upstream promoter; (ii) an upstream ...
G, van Marle, R G, van der Most, T, van der Straaten, W, Luytjes, W J, Spaan   +4 more
openaire   +2 more sources

The transcriptional regulation of pluripotency [PDF]

Cell Research, 2012
The defining features of embryonic stem cells (ESCs) are their self-renewing and pluripotent capacities. Indeed, the ability to give rise into all cell types within the organism not only allows ESCs to function as an ideal in vitro tool to study embryonic development, but also offers great therapeutic potential within the field of regenerative medicine.
Yeo, Jia-Chi, Ng, Huck-Hui
openaire   +3 more sources

Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation [PDF]

, 2017
International audienceOn the basis of nascent transcript sequencing, it has been postulated but never demonstrated that transcriptional pausing at translation start sites is important for gene regulation.
Dubé, Audrey, Perreault, Jonathan, Naghdi, Mohammad Reza, Chauvier, Adrien, Picard-Jean, Frédéric, Bastet, Laurène, Turcotte, Pierre, Lafontaine, Daniel A., Berger-Dancause, Jean-Christophe, Lafontaine, Daniel A   +9 more
core   +1 more source

Cell type and regulatory analysis in amphioxus illuminates evolutionary origin of the vertebrate head

Nature Communications
To shed light on the enigmatic origin of the vertebrate head, our study employs an integrated approach that combines single-cell transcriptomics, perturbations in signaling pathways, and cis-regulatory analysis in amphioxus.
Anna Markos, Jan Kubovciak, Simona Mikula Mrstakova, Anna Zitova, Jan Paces, Simona Machacova, Zbynek Kozmik-Jr, Zbynek Kozmik, Iryna Kozmikova   +8 more
doaj   +1 more source

The dual transcriptional regulator CysR in Corynebacterium glutamicum ATCC 13032 controls a subset of genes of the McbR regulon in response to the availability of sulphide acceptor molecules [PDF]

, 2008
Rückert C, Milse J, Albersmeier A, Koch DJ, Pühler A, Kalinowski J. The dual transcriptional regulator CysR in Corynebacterium glutamicum ATCC 13032 controls a subset of genes of the McbR regulon in response to the availability of sulphide acceptor ...
Rückert, Christian ; https://orcid.org/, Daniel J Koch, Johanna Milse, Koch, Daniel J., Albersmeier, Andreas, Christian Rückert, Pühler, Alfred ; https://orcid.org/, Kalinowski, Jörn, Alfred Pühler, Andreas Albersmeier, Milse, Johanna, Jörn Kalinowski, Kalinowski Jörn, Rückert Christian, Milse Johanna, Albersmeier Andreas, Pühler Alfred, Koch Daniel J   +17 more
core   +1 more source

Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle [PDF]

, 2015
Skeletal muscle cells exhibit an enormous plastic capacity in order to adapt to external stimuli. Even though our overall understanding of the molecular mechanisms that underlie phenotypic changes in skeletal muscle cells remains poor, several factors ...
Handschin, Christoph, Christoph Handschin, Kupr, Barbara, Barbara eKupr, Christoph eHandschin, Barbara Kupr, Handschin C, Kupr B   +7 more
core   +1 more source

Transcriptional Regulation by Nrf2

Antioxidants & Redox Signaling, 2018
Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes. Understanding the regulation of Nrf2 activity and downstream pathways has major implications for human health.
Tonelli, C., Chio, I. I. C., Tuveson, D. A.   +2 more
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Mechanism of PAX3-FKHR in transcriptional regulation

, 2009
[[abstract]]The PAX3-FKHR fusion protein is formed as a result of t(2;13) chromosomal translocations and functions as a transcription factor to activate transcription.
Ching-Yi Lin
core