Results 71 to 80 of about 962,811 (315)

Transcription Regulation in Archaea [PDF]

Journal of Bacteriology, 2016
ABSTRACTThe known diversity of metabolic strategies and physiological adaptations of archaeal species to extreme environments is extraordinary. Accurate and responsive mechanisms to ensure that gene expression patterns match the needs of the cell necessitate regulatory strategies that control the activities and output of the archaeal transcription ...
Alexandra M, Gehring, Julie E, Walker, Thomas J, Santangelo   +2 more
openaire   +2 more sources

Transcriptional gene silencing mutants in "Arabidopsis thaliana" and their impact on nuclear architecture and heterochromatin organization [PDF]

, 2004
The epigenetic regulation of gene expression is defined by covalent modifications of DNA and histone tails as well as by chromatin structure and nuclear architecture.
Valeska Probst, Aline
core   +1 more source

SLC25A11 Is Associated with KDM2A-Dependent Reduction in rRNA Transcription Induced by Aminooxyacetic Acid

Cells
The malate–aspartate shuttle (MAS) is an NADH shuttle that transports cytoplasmic reducing equivalents to the mitochondria for producing energy. We previously demonstrated that K-demethylase 2A (KDM2A), a jmjC-type histone demethylase, decreases ...
Yuji Tanaka, Nagisa Miyazawa, Yuuki Toba
doaj   +1 more source

Author Correction: Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm

Nature Communications, 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Sho Kubota, Kenji Tokunaga, Tomohiro Umezu, Takako Yokomizo-Nakano, Yuqi Sun, Motohiko Oshima, Kar Tong Tan, Henry Yang, Akinori Kanai, Eisaku Iwanaga, Norio Asou, Takahiro Maeda, Naomi Nakagata, Atsushi Iwama, Kazuma Ohyashiki, Motomi Osato, Goro Sashida   +16 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Transcriptional Regulation of Osteoblasts [PDF]

Cells Tissues Organs, 2007
The differentiation of osteoblasts from mesenchymal precursors requires a series of cell fate decisions controlled by a hierarchy of transcription factors. These include RUNX2, Osterix (OSX), ATF4 and a large number of nuclear coregulators. During bone development, initial RUNX2 expression coincides with the formation of mesenchymal condensations and ...
Franceschi, Renny T., Ge, Chunxi, Xiao, Guozhi, Roca, Hernan, Jiang, Di   +4 more
openaire   +5 more sources

Discovering transcriptional modules by Bayesian data integration [PDF]

, 2010
Motivation: We present a method for directly inferring transcriptional modules (TMs) by integrating gene expression and transcription factor binding (ChIP-chip) data.
Richard S. Savage, Wild, David L., Griffin, JE, Savage, RS, Bernard J. de la Cruz, Savage, Richard S., ,, De la Cruz, Bernard J., David L. Wild, de la Cruz, BJ, Wild, DL, Jim E. Griffin, Ghahramani, Z, Ghahramani, Zoubin, Griffin, Jim E., Zoubin Ghahramani   +15 more
core   +1 more source

Cell type and regulatory analysis in amphioxus illuminates evolutionary origin of the vertebrate head

Nature Communications
To shed light on the enigmatic origin of the vertebrate head, our study employs an integrated approach that combines single-cell transcriptomics, perturbations in signaling pathways, and cis-regulatory analysis in amphioxus.
Anna Markos, Jan Kubovciak, Simona Mikula Mrstakova, Anna Zitova, Jan Paces, Simona Machacova, Zbynek Kozmik-Jr, Zbynek Kozmik, Iryna Kozmikova   +8 more
doaj   +1 more source

Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm

Nature Communications, 2019
Translocation of (6;8)(p21;q24), a recurrent abnormality of blastic plasmacytoid dendritic cell neoplasm, involves adjacent MYC and RUNX2 regions. Here, the authors show that the RUNX2 super-enhancer is hijacked to activate MYC in addition to RUNX2 ...
Sho Kubota, Kenji Tokunaga, Tomohiro Umezu, Takako Yokomizo-Nakano, Yuqi Sun, Motohiko Oshima, Kar Tong Tan, Henry Yang, Akinori Kanai, Eisaku Iwanaga, Norio Asou, Takahiro Maeda, Naomi Nakagata, Atsushi Iwama, Kazuma Ohyashiki, Motomi Osato, Goro Sashida   +16 more
doaj   +1 more source

A Quarter Century History of ATML1 Gene Research

Plants, 2021
The cloning of the ATML1 gene, encoding an HD-ZIP class IV transcription factor, was first reported in 1996. Because ATML1 mRNA was preferentially detected in the shoot epidermis, cis-regulatory sequences of ATML1 have been used to drive gene expression ...
Hiroyuki Iida, Shinobu Takada
doaj   +1 more source