Results 111 to 120 of about 1,265,836 (379)
Connexins: synthesis, post-translational modifications, and trafficking in health and disease [PDF]
, 2018 Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs.
Aasen, Trond +5 more
core +3 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Genome-wide profiling of transcribed enhancers during macrophage activation
Epigenetics & Chromatin, 2017 Background Macrophages are sentinel cells essential for tissue homeostasis and host defence. Owing to their plasticity, macrophages acquire a range of functional phenotypes in response to microenvironmental stimuli, of which M(IFN-γ) and M(IL-4/IL-13 ...
Elena Denisenko +5 more
doaj +1 more source
Collective Properties of a Transcription Initiation Model under Varying Environment [PDF]
arXiv, 2015 The dynamics of gene transcription is tightly regulated in eukaryotes. Recent experiments have revealed various kinds of transcriptional dynamics, such as RNA polymerase II pausing, that involves regulation at the transcription initiation stage, and the choice of different regulation pattern is closely related to the physiological functions of the ...
arxiv
Encoding folding paths of RNA switches [PDF]
, 2006 RNA co-transcriptional folding has long been suspected to play an active role in helping proper native folding of ribozymes and structured regulatory motifs in mRNA untranslated regions.
Harlepp, S. +3 more
core +3 more sources
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
BMC Genomics, 2019 Background Tuberculosis is a life-threatening infectious disease caused by Mycobacterium tuberculosis (M.tb). M.tb subverts host immune responses to build a favourable niche and survive inside of host macrophages. Macrophages can control or eliminate the
Elena Denisenko +5 more
doaj +1 more source
Deciphering transcriptional dynamics in vivo by counting nascent RNA molecules [PDF]
, 2013 Transcription of genes is the focus of most forms of regulation of gene expression. Even though careful biochemical experimentation has revealed the molecular mechanisms of transcription initiation for a number of different promoters in vitro, the dynamics of this process in cells is still poorly understood.
arxiv +1 more source
The Energetics of Molecular Adaptation in Transcriptional Regulation [PDF]
, 2019 Mutation is a critical mechanism by which evolution explores the functional landscape of proteins. Despite our ability to experimentally inflict mutations at will, it remains difficult to link sequence-level perturbations to systems-level responses. Here,
Barnes, Stephanie L. +7 more
core +1 more source
Automated design of bacterial genome sequences [PDF]
, 2013 Background: Organisms have evolved ways of regulating transcription to better adapt to varying environments. Could the current functional genomics data and models support the possibility of engineering a genome with completely rearranged gene ...
Carrera, Javier, Jaramillo, Alfonso
core +4 more sources