Results 121 to 130 of about 4,769,934 (397)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

A Bcl11bN797K variant isolated from an immunodeficient patient inhibits early thymocyte development in mice

Frontiers in Immunology
BCL11B is a transcription factor with six C2H2-type zinc-finger domains. Studies in mice have shown that Bcl11b plays essential roles in T cell development.
Kazuaki Matsumoto, Kazuaki Matsumoto, Kazuki Okuyama, Tom Sidwell, Motoi Yamashita, Motoi Yamashita, Takaho Endo, Naoko Satoh-Takayama, Hiroshi Ohno, Tomohiro Morio, Ellen V. Rothenberg, Ichiro Taniuchi   +11 more
doaj   +1 more source

Genome-wide profiling of transcribed enhancers during macrophage activation

Epigenetics & Chromatin, 2017
Background Macrophages are sentinel cells essential for tissue homeostasis and host defence. Owing to their plasticity, macrophages acquire a range of functional phenotypes in response to microenvironmental stimuli, of which M(IFN-γ) and M(IL-4/IL-13 ...
Elena Denisenko, Reto Guler, Musa M. Mhlanga, Harukazu Suzuki, Frank Brombacher, Sebastian Schmeier   +5 more
doaj   +1 more source

Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila. [PDF]

, 2015
Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms in physiology and behavior with the 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping,
Chiu, Joanna C, Kwok, Rosanna S, Lam, Vu H   +2 more
core   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Cell-type specific, inducible and acute degradation of targeted protein in mice by two degron systems

Nature Communications
Despite its broad application in in vitro studies, the application of targeted protein degradation (TPD) to animal models faces considerable challenges. Here, we develop inducible and cell-type specific TPD systems in mice using two degron systems: Oryza
Motoi Yamashita, Chihiro Ogawa, Baihao Zhang, Tetsuro Kobayashi, Aneela Nomura, Clive Barker, Chengcheng Zou, Satoshi Yamanaka, Ken-ichiro Hayashi, Yoichi Shinkai, Kazuyo Moro, Sidonia Fargarasan, Koshi Imami, Jun Seita, Fumiyuki Shirai, Tatsuya Sawasaki, Masato T. Kanemaki, Ichiro Taniuchi   +17 more
doaj   +1 more source

Characterization of an induced pluripotent stem cell line (IMBPASi001-A) derived from fibroblasts of a patient affected by Wolfram Syndrome

Stem Cell Research, 2020
Wolfram Syndrome is a rare, autosomal recessive genetic disorder with clinical symptoms appearing in early childhood. Here, we report a generation of iPSCs from fibroblasts of a patient affected by this disease.
Dawid P. Grzela, Beata Marciniak, Lukasz Pulaski   +2 more
doaj  

Transcriptionally induced enhancers in the macrophage immune response to Mycobacterium tuberculosis infection

BMC Genomics, 2019
Background Tuberculosis is a life-threatening infectious disease caused by Mycobacterium tuberculosis (M.tb). M.tb subverts host immune responses to build a favourable niche and survive inside of host macrophages. Macrophages can control or eliminate the
Elena Denisenko, Reto Guler, Musa Mhlanga, Harukazu Suzuki, Frank Brombacher, Sebastian Schmeier   +5 more
doaj   +1 more source

Calcium Signaling and Transcriptional Regulation in Cardiomyocytes.

Circulation Research, 2017
Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes, Ca2+ is the central element of excitation-contraction coupling, but also impacts diverse signaling cascades and influences the regulation of gene expression ...
M. Dewenter, Albert von der Lieth, H. Katus, J. Backs   +3 more
semanticscholar   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source