Results 281 to 290 of about 962,811 (315)
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Transcriptional Regulation of Myelopoiesis
International Journal of Hematology, 2002A common myeloid progenitor gives rise to both granulocytes and monocytes. The early stages of granulopoiesis are mediated by the C/EBPalpha, PU.1, RAR, CBF, and c-Myb transcription factors, and the later stages require C/EBPepsilon, PU.1, and CDP. Monocyte development requires PU.1 and interferon consensus sequence binding protein and can be induced ...
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BRCA1 regulation of transcription
Cancer Letters, 2006BRCA1, a tumor suppressor gene on chromosome 17q21, was identified in 1994 based on its linkage to hereditary breast and ovarian cancer syndromes. The BRCA1 gene encodes a 220 kDa nuclear phosphoprotein. Studies aimed at elucidating the mechanisms of its tumor suppressor activity have revealed, in part, that BRCA1 participates in the DNA damage ...
Eliot M, Rosen +2 more
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Transcriptional regulation of ADAMTS13
Thrombosis and Haemostasis, 2005SummaryThe metalloproteinase ADAMTS13 cleaves VWF multimers instantaneously when they are released from endothelial cells. Absent or manifestly diminished proteolytic activity of ADAMTS13 results in the appearance and accumulation of ultralarge VWF multimers (ULVWFM) in plasma, characterised by the manifestation of Thrombotic Thrombocytopenic Purpura ...
Claus, Ralf A. +7 more
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FOXM1 transcriptional regulation
Biology of the CellAbstractFOXM1 is a key transcriptional regulator involved in various biological processes in mammals, including carbohydrate and lipid metabolism, aging, immune regulation, development, and disease. Early studies have shown that FOXM1 acts as an oncogene by regulating cell proliferation, cell cycle, migration, metastasis, and apoptosis, as well as ...
Mengxi Li +6 more
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Transcriptional regulation in Archaea
Current Opinion in Genetics & Development, 2004During the past few decades, it has become clear that microorganisms can thrive under the most diverse conditions, including extremes of temperature, pressure, salinity and pH. Most of these extremophilic organisms belong to the third domain of life, that of the Archaea. The organisms of this domain are of particular interest because most informational
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Transcriptional regulation by cAMP
Current Biology, 1991Cyclic AMP regulates a myriad of cellular processes through the cAMP-dependent protein kinase A. In many cases, activation of protein kinase A leads to altered patterns of gene transcription. Identification of the cAMP-response-element-binding-protein as a major nuclear substrate for protein kinase A accounts for many recent advances in understanding ...
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AMPK and transcriptional regulation
Frontiers in Bioscience, 2008The AMP-activated protein kinase (AMPK) is an energy sensing enzyme that once activated, promotes energy production and limits energy utilisation to ensure cellular survival. In addition to targeting numerous metabolic enzymes for this purpose, it is becoming apparent that AMPK can also regulate a number of transcriptional processes.
Sean L, McGee, Mark, Hargreaves
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Transcriptional Regulation in Melanoma
Hematology/Oncology Clinics of North America, 2009Transcriptional regulation in melanoma is a complex process that tends to hijack the normal melanocyte signaling pathways involved in melanocyte development, pigmentation, and survival. At the center of these often overlapping networks of transcriptional activation and repression is microphthalmia-associated transcription factor (MITF), a melanocyte ...
Devarati, Mitra, David E, Fisher
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SUMO and transcriptional regulation
Seminars in Cell & Developmental Biology, 2004The small ubiquitin-like modifier (SUMO) is covalently attached to lysine residues in target proteins and in doing so changes the properties of the modified protein. Here we examine the role of SUMO modification in transcriptional regulation. SUMO addition to components of the transcriptional apparatus does not have a common consequence as it can both ...
David W H, Girdwood +2 more
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Transcriptional regulation in lymphocytes
Current Opinion in Cell Biology, 2001Lymphocytes have been used to investigate many cellular processes, including lineage commitment, differentiation, proliferation and apoptosis. The transcription factors that mediate these processes are often expressed broadly in many cell types. The emerging theme is one of cell-type-specific regulation, affecting not only the functional activation of ...
H, Okamura, A, Rao
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