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Transcriptional Regulation and Pharmacogenomics [PDF]
Pharmacogenomics, 2011 Interindividual variable drug response is correlated with sequence alterations in genes encoding drug-metabolizing enzymes and transporters, affecting drug absorption, distribution, metabolism and excretion. This variable drug response may have an impact on disease therapeutic outcomes, tolerance to adverse drug reactions and even survival.
Georgitsi, Marianthi +3 more
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Actin in transcription and transcription regulation
Current Opinion in Cell Biology, 2006Recent research has provided convincing evidence that actin plays several important roles in gene transcription. First, actin can bind transcription factors and determine their subcellular localization. Second, actin is a component of chromatin remodeling complexes involved in transcriptional activation.
Francesc Miralles, Neus Visa
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Transcriptional regulation and metabolism
Biochemical Society Transactions, 2005Understanding organisms from a systems perspective is essential for predicting cellular behaviour as well as designing gene-metabolic circuits for novel functions. The structure, dynamics and interactions of cellular networks are all vital components of systems biology.
Mark P. Brynildsen +2 more
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Transcriptional Regulation of Adipogenesis
Comprehensive Physiology, 2017ABSTRACTAdipocytes are the defining cell type of adipose tissue. Once considered a passive participant in energy storage, adipose tissue is now recognized as a dynamic organ that contributes to several important physiological processes, such as lipid metabolism, systemic energy homeostasis, and whole‐body insulin sensitivity.
Jacqueline M. Stephens +3 more
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Transcription Regulation in Spermatogenesis
2009Spermatogenesis is a highly coordinated process in which diploid spermatogonia (2n) differentiate into mature haploid (1n) spermatozoa in the seminiferous epithelium. In this process, spermatogonia undergo several mitotic divisions and either enter a stem cell renewal pathway, or commit themsevles for further development.
Lui, WY, Cheng, CY
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Mediator of transcriptional regulation
Trends in Biochemical Sciences, 1996A multi-protein complex, termed mediator, has been isolated from yeast, based on its requirement for transcriptional activation in a system reconstituted from pure RNA polymerase II and general transcription factors. Mediator polypeptides include the products of many genes previously recovered from screens for mutations affecting transcription.
Young Joon Kim, Stefan Björklund
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Transcriptional regulation of hemopoiesis
Developmental & Comparative Immunology, 2001The regulation of blood cell formation, or hemopoiesis, is central to the replenishment of mature effector cells of innate and acquired immune responses. These cells fulfil specific roles in the host defense against invading pathogens, and in the maintenance of homeostasis.
Daniel R. Barreda, Miodrag Belosevic
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Transcriptional regulation by cAMP
Current Biology, 1991Cyclic AMP regulates a myriad of cellular processes through the cAMP-dependent protein kinase A. In many cases, activation of protein kinase A leads to altered patterns of gene transcription. Identification of the cAMP-response-element-binding-protein as a major nuclear substrate for protein kinase A accounts for many recent advances in understanding ...
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Transcriptional Regulation of Metabolism
Physiological Reviews, 2006Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made towards elucidating the mechanisms controlling the major regulatory pathways are now being rewarded. At the molecular level, the crucial role of transcription factors is particularly well-illustrated by the link between alterations of their functions and the ...
Liliane Michalik +2 more
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Chromatin and transcription regulation
Molecular Biology, 2007Recent years are marked by drastic increase of interest in the role of chromatin in regulation of gene activity. In the seventies of the last century many studies were undertaken in order to identify different forms of histones involved in regulation on transcription. The results of these studies were conflicting. Determination of primary structures of
Sergey V. Razin, Sergey V. Razin
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