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Transcriptional regulation of BRCA1 [PDF]
, 1999 Abstract : Germline mutations in BRCAl lead to an increased risk of breast and ovarian cancer, with loss of the second, normal allele critical to tumorigenesis. It was widely presumed that the cloning and characterization of genes involved in hereditary breast cancer would lead to a better understanding of the genesis of the more common non-inherited ...
Shannon R. Payne, Mary C. King
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Transcriptional Regulation of Myelopoiesis
International Journal of Hematology, 2002A common myeloid progenitor gives rise to both granulocytes and monocytes. The early stages of granulopoiesis are mediated by the C/EBPalpha, PU.1, RAR, CBF, and c-Myb transcription factors, and the later stages require C/EBPepsilon, PU.1, and CDP. Monocyte development requires PU.1 and interferon consensus sequence binding protein and can be induced ...
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Mechanogenetic regulation of transcription
Biochimie, 1991In many biological systems mechanical forces regulate gene expression: in bacteria changes in turgor pressure cause a deformation of the membrane and induce the expression of osmoregulatory genes; in plants gravity regulates cell growth ('geotropism'); in mammals stretching a muscle induces hypertrophy which is accompanied by qualitative changes in ...
L. Rappaport +2 more
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Transcriptional regulation of ADAMTS13
Thrombosis and Haemostasis, 2005SummaryThe metalloproteinase ADAMTS13 cleaves VWF multimers instantaneously when they are released from endothelial cells. Absent or manifestly diminished proteolytic activity of ADAMTS13 results in the appearance and accumulation of ultralarge VWF multimers (ULVWFM) in plasma, characterised by the manifestation of Thrombotic Thrombocytopenic Purpura ...
Claus, Ralf A. +7 more
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BRCA1 regulation of transcription
Cancer Letters, 2006BRCA1, a tumor suppressor gene on chromosome 17q21, was identified in 1994 based on its linkage to hereditary breast and ovarian cancer syndromes. The BRCA1 gene encodes a 220 kDa nuclear phosphoprotein. Studies aimed at elucidating the mechanisms of its tumor suppressor activity have revealed, in part, that BRCA1 participates in the DNA damage ...
Yongxian Ma, Saijun Fan, Eliot M. Rosen
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DnaA as a Transcription Regulator
2003Publisher Summary This chapter reviews that DnaA is a transcription factor involved in the regulation of several E. Coli genes. DnaA can act as a repressor or it can be a transcriptional activator. DnaA might terminate transcription, provided two suitably located DnaA boxes mediate loop formation of the template.
Christoph Weigel, Walter Messer
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Nucleosomes: regulators of transcription
Trends in Genetics, 1990Histones and nucleosomes are involved in the folding of DNA in the eukaryotic cell. Recent evidence suggests that they are also involved in a multistep process of DNA unfolding and gene regulation.
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Transcriptional regulation in Archaea
Current Opinion in Microbiology, 1999Information regarding transcriptional regulation in Archaea has begun to emerge from in vivo genetic studies. Evidence to date suggests a varied repertoire of regulatory mechanisms in Archaea that invokes both bacterial and eukaryal paradigms, as well as some novel features.
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Mechanisms of Transcriptional Regulation
1999The phenomenon of genomic imprinting, whatever its biological functions and evolutionary origins may be, ultimately manifests itself in the monoallelic expression of certain genes. The assumption has been, therefore, that the transcriptional regulatory systems of imprinted genes would directly or indirectly represent the principal focus of the ...
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Transcriptional regulation in Archaea
Current Opinion in Genetics & Development, 2004During the past few decades, it has become clear that microorganisms can thrive under the most diverse conditions, including extremes of temperature, pressure, salinity and pH. Most of these extremophilic organisms belong to the third domain of life, that of the Archaea. The organisms of this domain are of particular interest because most informational
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