Results 131 to 140 of about 8,166 (222)

Transcriptome-Wide Association Study Reveals New Molecular Interactions Associated with Melanoma Pathogenesis

Cancers
Simple Summary The journey of discovering melanoma—the most dangerous type of skin cancer—biomarkers is never-ending. Under that assumption, this study attempts to partially fill a gap in that journey by identifying melanoma-related biomarkers.
Mohamed N. Saad, Mohamed Hamed
semanticscholar   +1 more source

Synovial transcriptome-wide association study implicates novel genes underlying rheumatoid arthritis risk.

Rheumatology
OBJECTIVES This study aimed to address the lack of gene expression regulation data in synovial tissues and to identify conditionally independent genes associated with rheumatoid arthritis (RA) in the synovium, a primary target tissue for RA.
Shouye Hu, Feng Jiang, Huimiao Song, Yakang Wang, Wen Tian, Hao Wu, S. Yao, Chang-Yi He, Hui-Wu Gao, Tie-Lin Yang, Zhi Yang, Yan Guo   +11 more
semanticscholar   +1 more source

A transcriptome-wide association study identified susceptibility genes for hepatocellular carcinoma in East Asia

Gastroenterology Report
Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is prevalent in East Asia. Although genome-wide association studies (GWASs) of HCC have identified 23 risk regions, the susceptibility genes underlying these ...
Jingjing Zhang, Qingrong Zhang, Wenyan Hu, Yuxuan Liang, Deke Jiang, Haitao Chen   +5 more
semanticscholar   +1 more source

Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes

Nature Communications
Genome-wide association studies have suggested numerous colorectal cancer (CRC) susceptibility genes, but their causality and therapeutic potential remain unclear.
Emma Hazelwood, Daffodil M. Canson, Benedita Deslandes, Xuemin Wang, Pik Fang Kho, Danny Legge, Andrei-Emil Constantinescu, Matthew A. Lee, D. Timothy Bishop, Andrew T. Chan, Stephen B. Gruber, Jochen Hampe, Loic Le Marchand, Michael O. Woods, Rish K. Pai, Stephanie L. Schmit, Jane C. Figueiredo, Wei Zheng, Jeroen R. Huyghe, Neil Murphy, Marc J. Gunter, Tom G. Richardson, Vicki L. J. Whitehall, Emma E. Vincent, Dylan M. Glubb, Tracy A. O’Mara   +25 more
doaj   +1 more source

Identification of novel proteins associated with intelligence by integrating genome-wide association data and human brain proteomics.

PLoS ONE
While genome-wide association studies (GWAS) have identified genetic variants associated with intelligence, their biological mechanisms remain largely unexplored.
Zheng Zhang, Yousong Zhu, Junlong Zhang, Wenbin He, Cheng Han   +4 more
doaj   +1 more source

Identifying microRNA Biomarkers in Prostate Cancer: A Transcriptome-Wide Association Studies (TWAS) [PDF]

, 2020
Dulari K. Jayarathna, Miguel E. Rentería, Jyotsna Batra, Emilie Sauret, Samaneh Farashi, Neha S. Gandhi   +5 more
openalex  

scPrediXcan integrates advances in deep learning and single-cell data into a powerful cell-type–specific transcriptome-wide association study framework

bioRxiv
Transcriptome-wide association studies (TWAS) help identify disease causing genes, but often fail to pinpoint disease mechanisms at the cellular level because of the limited sample sizes and sparsity of cell-type–specific expression data. Here we propose
Yichao Zhou, Temidayo Adeluwa, Lisha Zhu, Sofia Salazar-Magaña, Sarah Sumner, Hyunki Kim, Saideep Gona, F. Nyasimi, Rohit Kulkarni, Joseph E. Powell, Ravi Madduri, Boxiang Liu, Mengjie Chen, Hae Kyung Im   +13 more
semanticscholar   +1 more source

Trans-Ancestry Analysis of Psychosis Biotypes: Shared Polygenic Risk and Unique Genomic Associations [PDF]

The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) has categorized psychosis disorders (Schizophrenia, Schizoaffective Disorder and Bipolar Disorder) into three distinct Biotypes, based on neurobiological measurements in a multi ...
Alliey-Rodriguez, Ney, Bishop, Jeffrey R., Gershon, Elliot S., Hill, Scot, Keedy, Sarah K., Keshavan, Matcheri S., Lencer, Rebekka, Parker, David, Pearlson, Godfrey D., Tamminga, Carol A   +9 more
core   +1 more source

Brain transcriptome-wide association studies in diverse ancestral populations reveal genes implicated in an anxiety-related phenotype. [PDF]

G3 (Bethesda)
Sharma MZ, Wheeler HE.
europepmc   +1 more source

Identification of genes associated with testicular germ cell tumor susceptibility through a transcriptome-wide association study [PDF]

\ua9 2025 The Author(s). Transcriptome-wide association studies (TWASs) have the potential to identify susceptibility genes associated with testicular germ cell tumors (TGCTs). We conducted a comprehensive TGCT TWAS by integrating genome-wide association
Aben KK, Almstrup K, Anson-Cartwright L, Chanock SJ, Chen C, Cortessis VK, Damra M, Daneshmand S, Fan M, Ferlin A, Gamulin M, Gietema JA, Gonzalez-Niera A, Grotmol T, Hamilton RJ, Harland M, Haugen TB, Hauser R, Hildebrandt MAT, Kanetsky PA, Karlsson R, Kiemeney LA, Kim J, Lessel D, Lothe RA, Loveday C, McGlynn KA, Meijer C, Monteiro AN, Nathanson KL, Nead KT, Nsengimana J, Ploner A, Pluta J, Popovic M, Rafnar T, Richiardi L, Rocca MS, Schwartz SM, Skotheim RI, Stefansson K, Stewart DR, Turnbull C, Ugalde-Morales E, Vaughn DJ, Wiklund F, Wilf R, Winge SB, Zheng T   +48 more
core