Results 151 to 160 of about 426,916 (271)

Étude des transcriptomes par analyse sérielle de l’expression des gènes [PDF]

, 2002
Jacques Marti, David Piquemal, Laurent Manchon, Thérèse Commes   +3 more
openalex   +1 more source

RNF112 Facilitates Ubiquitin‐Mediated Degradation of c‐Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer

Advanced Science, EarlyView.
RNF112, an E3 ubiquitin ligase, is markedly reduced in bladder cancer (BLCA). It curbs BLCA cell proliferation, migration, and lipid production primarily by enhancing ubiquitin‐dependent degradation of c‐Myc. This degradation inhibits c‐Myc's role in upregulating ACLY, a crucial enzyme for lipid synthesis, highlighting RNF112's potential as a ...
Kangping Xiong, Siming Chen, Huimin Xu, Sheng Tu, Hong Weng, Yejinpeng Wang, Mingxing Li, Jingtian Yu, Kaiyu Qian, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Gang Wang   +13 more
wiley   +1 more source

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

De novo transcriptome assembly of the plant Helianthemum marifolium for the study of adaptive mechanisms. [PDF]

Sci Data
Martín-Díaz A, de Vega C, Martín-Hernanz S, Aparicio A, Albaladejo RG.   +4 more
europepmc   +1 more source

Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4‐Mediated Ferritinophagy Associated with Cisplatin‐Induced Hearing Loss

Advanced Science, EarlyView.
Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen, Cheng Cheng, Ao Li, Dengbin Ma, Siyu Li, Handong Wang, Song Gao, Dingding Liu, Panpan Song, Chenjie Yu, Xiaoyun Qian, Guoqiang Wan, Xia Gao   +12 more
wiley   +1 more source

De Novo transcriptome assembly and annotation of the wild service tree Sorbus torminalis (L.) Crantz. [PDF]

BMC Res Notes
Pinosio S, Avanzi C, Bagnoli F, Spanu I, Vendramin GG, Piotti A.   +5 more
europepmc   +1 more source

Transcriptome profiling to identify genes involved in peroxisome assembly and function [PDF]

, 2002
Jennifer J. Smith, Marcello Marelli, Rowan H. Christmas, Franco J. Vizeacoumar, David J. Dilworth, Trey Ideker, Timothy Galitski, Krassen Dimitrov, Richard A. Rachubinski, John D. Aitchison   +9 more
openalex   +1 more source

Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge‐Weber Syndrome Pathogenesis

Advanced Science, EarlyView.
Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformations, leading to seizures and stroke. Analysis of 119 446 brain cells from SWS patients uncovered distinct cell heterogeneity and identified an EDN3⁺ meningeal fibroblast cluster, with WNT5A emerging as a potential key driver of SWS progression and a promising therapeutic ...
Daosheng Ai, Tianyue Ming, Xiaoli Li, Shu Wang, Zhanying Bi, Jinyi Zuo, Zizhang Cheng, Weijin Sun, Mingguo Xie, Fengzhi Li, Xiongfei Wang, Xueling Qi, Guoming Luan, Woo‐ping Ge, Yuguang Guan   +14 more
wiley   +1 more source

Environmental drivers and transcriptomic variations shaping Lei bamboo shoots across cultivation regions. [PDF]

Front Plant Sci
Qian Y, Jia J, Chen Z, Wang K, Li P, Gao P, Ying Y, Shi W.   +7 more
europepmc   +1 more source

Introduction: from genome to function – monitoring global responses in infectious diseases by interrogating the transcriptome and proteome

, 2001
Stefan H. E. Kaufmann
openalex   +1 more source