Results 21 to 30 of about 474,674 (279)

Palindrome-mediated Translocations in Humans: A New Mechanistic Model for Gross Chromosomal Rearrangements

open access: yesFrontiers in Genetics, 2016
Palindromic DNA sequences, which can form secondary structures, are widely distributed in the human genome. Although the nature of the secondary structure—single-stranded hairpin or double-stranded cruciform—has been extensively investigated in vitro ...
Hidehito Inagaki   +8 more
doaj   +1 more source

Expansion of the SOS regulon of Vibrio cholerae through extensive transcriptome analysis and experimental validation

open access: yesBMC Genomics, 2018
Background The SOS response is an almost ubiquitous response of cells to genotoxic stresses. The full complement of genes in the SOS regulon for Vibrio species has only been addressed through bioinformatic analyses predicting LexA binding box consensus ...
Evelyne Krin   +12 more
doaj   +1 more source

Role of the Solute-Binding Protein CuaD in the Signaling and Regulating Pathway of Cellobiose and Cellulose Utilization in Ruminiclostridium cellulolyticum

open access: yesMicroorganisms, 2023
In Ruminiclostridium cellulolyticum, cellobiose is imported by the CuaABC ATP-binding cassette transporter containing the solute-binding protein (SBP) CuaA and is further degraded in the cytosol by the cellobiose phosphorylase CbpA.
Aurélie Fosses   +7 more
doaj   +1 more source

Fungal Transcriptomics

open access: yes, 2018
Transcriptomics, the study of RNA molecules, provides in-depth understanding of cellular functions and the genomic landscape of transcription. Transcriptomics refers to the study of all classes on RNA molecules including mRNA, tRNA, and siRNA. In this chapter, we specifically focus on mRNA, which encodes the protein-coding portion of the genomic DNA ...
Singan, Vasanth R   +2 more
openaire   +4 more sources

Analysis of splice variants of the human protein disulfide isomerase (P4HB) gene

open access: yesBMC Genomics, 2020
Background Protein Disulfide Isomerases are thiol oxidoreductase chaperones from thioredoxin superfamily with crucial roles in endoplasmic reticulum proteostasis, implicated in many diseases.
Daniela Kajihara   +9 more
doaj   +1 more source

Influence of SARS-CoV-2 Variant B.1.1.7, Vaccination, and Public Health Measures on the Spread of SARS-CoV-2

open access: yesViruses, 2021
The spread of SARS-CoV-2 and the resulting disease COVID-19 has killed over 2.6 million people as of 18 March 2021. We have used a modified susceptible, infected, recovered (SIR) epidemiological model to predict how the spread of the virus in regions of ...
Chloé Dimeglio   +10 more
doaj   +1 more source

Comparative analysis of viral RNA signatures on different RIG-I-like receptors

open access: yeseLife, 2016
The RIG-I-like receptors (RLRs) play a major role in sensing RNA virus infection to initiate and modulate antiviral immunity. They interact with particular viral RNAs, most of them being still unknown.
Raul Y Sanchez David   +10 more
doaj   +1 more source

The Redox Homeostasis of Skeletal Muscle Cells Regulates Stage Differentiation of Toxoplasma gondii

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
Toxoplasma gondii is an obligatory intracellular parasite that causes persistent infections in birds and mammals including ~30% of the world’s human population.
Md. Taibur Rahman   +8 more
doaj   +1 more source

The Intestinal Microbiota Interferes with the microRNA Response upon Oral Listeria Infection

open access: yesmBio, 2013
The intestinal tract is the largest reservoir of microbes in the human body. The intestinal microbiota is thought to be able to modulate alterations of the gut induced by enteropathogens, thereby maintaining homeostasis.
Cristel Archambaud   +8 more
doaj   +1 more source

Macromolecular crowding links ribosomal protein gene dosage to growth rate in Vibrio cholerae

open access: yesBMC Biology, 2020
Background In fast-growing bacteria, the genomic location of ribosomal protein (RP) genes is biased towards the replication origin (oriC). This trait allows optimizing their expression during exponential phase since oriC neighboring regions are in higher
Alfonso Soler-Bistué   +11 more
doaj   +1 more source

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