Results 61 to 70 of about 450,406 (197)
High-Frequency Promoter Firing Links THO Complex Function to Heavy Chromatin Formation
Cell Reports, 2013 The THO complex is involved in transcription, genome stability, and messenger ribonucleoprotein (mRNP) formation, but its precise molecular function remains enigmatic.
John Mouaikel +8 more
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Neoplasia: An International Journal for Oncology Research, 2006 In this study, we investigated the time course gene expression profile of preneoplastic nodules and hepatocellular carcinomas (HCC) to define the genes implicated in cancer progression in a resistant hepatocyte model. Tissues that included early nodules (
Julio Isael Pérez-Carréon +9 more
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Nature CommunicationsLong-read RNA sequencing is essential to produce accurate and exhaustive annotation of eukaryotic genomes. Despite advancements in throughput and accuracy, achieving reliable end-to-end identification of RNA transcripts remains a challenge for long-read ...
Sílvia Carbonell-Sala +9 more
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BMC Genomics, 2018 Background Without knowledge of their genomic sequences, it is impossible to make functional models of the bacteria that make up human and animal microbiota.
Luis Acuña-Amador +4 more
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The transcriptome of Toxoplasma gondii
BMC Biology, 2005 AbstractBackgroundToxoplasma gondiigives rise to toxoplasmosis, among the most prevalent parasitic diseases of animals and man. Transformation of the tachzyoite stage into the latent bradyzoite-cyst form underlies chronic disease and leads to a lifetime risk of recrudescence in individuals whose immune system becomes compromised.
Michael S. Behnke +5 more
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In Situ Fixation Redefines Quiescence and Early Activation of Skeletal Muscle Stem Cells
Cell Reports, 2017 Summary: State of the art techniques have been developed to isolate and analyze cells from various tissues, aiming to capture their in vivo state. However, the majority of cell isolation protocols involve lengthy mechanical and enzymatic dissociation ...
Léo Machado +10 more
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Transcriptome and Temporal Transcriptome Analyses in Single Cells
International Journal of Molecular SciencesTranscriptome analysis in single cells, enabled by single-cell RNA sequencing, has become a prevalent approach in biomedical research, ranging from investigations of gene regulation to the characterization of tissue organization. Over the past decade, advances in single-cell RNA sequencing technology, including its underlying chemistry, have ...
Jun Lyu, Chongyi Chen
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The plasticity of the mammalian transcriptome
Genomics, 2010 The dogmatic view of RNA as a mere necessity in the transfer of information between DNA and proteins has during recent years come into question. Novel approaches and new technology has revealed an unprecedented level of inherent complexity in the mammalian transcriptome.
Johan Lindberg, Joakim Lundeberg
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Haematologica, 2018 Hematopoietic differentiation is driven by transcription factors, which orchestrate a finely tuned transcriptional network. At bipotential branching points lineage decisions are made, where key transcription factors initiate cell type-specific gene ...
Stefanie C. Herkt +9 more
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The Olfactory Transcriptomes of Mice
PLoS Genetics, 2014 The olfactory (OR) and vomeronasal receptor (VR) repertoires are collectively encoded by 1700 genes and pseudogenes in the mouse genome. Most OR and VR genes were identified by comparative genomic techniques and therefore, in many of those cases, only their protein coding sequences are defined.
Ximena Ibarra-Soria +3 more
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