Results 111 to 120 of about 7,548,191 (313)

The Effect of Plastic-Related Compounds on Transcriptome-Wide Gene Expression on CYP2C19-Overexpressing HepG2 Cells. [PDF]

Molecules, 2023
Rosellini M, Schulze A, Omer EA, Ali NT, Marini F, Küpper JH, Efferth T.   +6 more
europepmc   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

Systematic analysis of a novel human renal glomerulus-enriched gene expression dataset [PDF]

, 2010
Glomerular diseases account for the majority of cases with chronic renal failure. Several genes have been identified with key relevance for glomerular function.
Clemens D Cohen, Ilka Edenhofer, Felix Eichinger, Rastaldi, Maria P., Maja T. Lindenmeyer, Hans-Joachim Anders, Lindenmeyer, M T, Cohen Clemens D., Eichinger, Felix, Eichinger Felix, Kretzler, Matthias, Mattinzoli, D, Deborah Mattinzoli, Maja T Lindenmeyer, Maria P. Rastaldi, Cohen, Clemens D., Kretzler, M, Sen, Kontheari, Rastaldi Maria P., Matthias Kretzler, Edenhofer, I, Lindenmeyer, Maja T., Anders Hans-Joachim, Clemens D. Cohen, Cohen, C D, Maria P Rastaldi, Mattinzoli Deborah, Mattinzoli, Deborah, Anders, Hans-Joachim, Sen Kontheari, Kretzler Matthias, Edenhofer, Ilka, Kontheari Sen, Lindenmeyer Maja T., Rastaldi, M P, Edenhofer Ilka, Eichinger, F, Sen, K, Mattinzoli D, Anders HJ, Eichinger F, Lindenmeyer MT, Cohen CD, Sen K, Kretzler M, Rastaldi MP, Edenhofer I   +46 more
core   +1 more source

Full-Length Transcriptome and Gene Expression Analysis of Different Ovis aries Adipose Tissues Reveals Transcript Variants Involved in Lipid Biosynthesis. [PDF]

Animals (Basel), 2023
An L, Pan Y, Yuan M, Wen Z, Qiao L, Wang W, Liu J, Li B, Liu W.   +8 more
europepmc   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Mean Expression of the X-Chromosome is Associated with Neuronal Density. [PDF]

, 2012
peer reviewedBackground: Neurodegenerative diseases are characterized by key features such as loss of neurons, astrocytosis, and microglial activation/proliferation. These changes cause differences in the density of cell types between control and disease
Pascal F. Durrenberger, James Thomas Swingland, Durrenberger, Pascal F, Swingland, James T., Reynolds, Richard, DEPREZ, Manuel, Pombo, A., Deprez, M, Roncaroli, F, Durrenberger, P.F., David T Dexter, Richard eReynolds, Dexter, DT, Turkheimer, Federico E; id_orcid, Turkheimer, Federico E., James T. Swingland, Ana Pombo, Federico Roncaroli, Turkheimer, FE, Swingland, J.T., Durrenberger, PF, David T. Dexter, Pombo, Ana, Dexter, David T, Durrenberger, Pascal F., Reynolds, R, Turkheimer, F.E., Manuel eDeprez, Swingland, James T, Federico E. Turkheimer, Dexter, D.T., Roncaroli, Federico, Federico eRoncaroli, Richard Reynolds, Reynolds, R., Turkheimer, Federico E, Manuel Deprez, Pombo, A, Pascal F Durrenberger, Ana ePombo, Dexter, David T., Deprez, M., Roncaroli, F., Swingland, JT   +43 more
core   +1 more source

The trypanosome transcriptome is remodelled during differentiation but displays limited responsiveness within life stages

BMC Genomics, 2008
Background Trypanosomatids utilise polycistronic transcription for production of the vast majority of protein-coding mRNAs, which operates in the absence of gene-specific promoters. Resolution of nascent transcripts by polyadenylation and trans-splicing,
Sergeenko Tatiana, Natesan Senthil, Koumandou V Lila, Field Mark C   +3 more
doaj   +1 more source

A full-length transcriptome and gene expression analysis of three detoxification gene families in a predatory stink bug, Picromerus lewisi. [PDF]

Front Physiol, 2022
Li W, Wang X, Jiang P, Yang M, Li Z, Huang C, He Y.   +6 more
europepmc   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Evolution of the Aging Brain Transcriptome and Synaptic Regulation [PDF]

, 2008
Alzheimer's disease and other neurodegenerative disorders of aging are characterized by clinical and pathological features that are relatively specific to humans.
Dakin Kelly A., Isaacs Adrian, Prolla Tomas A., Pan, Y, Gabuzda Dana H., Geula Chengiz, Li, C, Jianbin Wang, Pan Ying, Wang, J, Dakin, KA, Bruce A Yankner, Adrian Isaacs, Ying Pan, Isaacs, A, Gabuzda, DH, Tao Lu, Yankner Bruce A., Cheng Li, Geula, C, Tomas A Prolla, Loerch, PM, Prolla, TA, Lu, T, Yankner, BA, Li Cheng, Wang Jianbin, Chengiz Geula, Kelly A Dakin, Dana H Gabuzda, Patrick M Loerch, Loerch Patrick M., Vann, JM, Lu Tao, Vann James M., James M Vann   +35 more
core   +2 more sources