Results 71 to 80 of about 7,548,191 (313)

Tools for building de novo transcriptome assembly

Current Plant Biology, 2017
The availability of RNA-Seq method allows researchers to capture the spatial or temporal profile of transcriptomes from various types of biological samples.
Matthew Geniza, Pankaj Jaiswal
doaj   +1 more source

Gene expression variability: the other dimension in transcriptome analysis [PDF]

Physiological Genomics, 2019
Transcriptome sequencing is a powerful technique to study molecular changes that underlie the differences in physiological conditions and disease progression. A typical question that is posed in such studies is finding genes with significant changes between sample groups.
Tristan V, de Jong, Yuri M, Moshkin, Victor, Guryev   +2 more
openaire   +2 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Expert Curation of Human Microarray Probe Annotations in the Biological Interpretation of Integrated Transcriptome Analyses

BioMedInformatics
Background: Accurate mapping of microarray probes to gene loci is essential for a reliable interpretation of gene expression data, yet available probe annotations are often incomplete or outdated.
Beatrice Vione, Francesca Antonaros, Andrea Barbarossa, Giulia Salatino, Lorenza Vitale, Pierluigi Strippoli, Maria Chiara Pelleri, Maria Caracausi, Allison Piovesan   +8 more
doaj   +1 more source

Transcriptome Analysis of Diurnal Gene Expression in Chinese Cabbage [PDF]

Genes, 2019
Plants have developed timing mechanisms that enable them to maintain synchrony with daily environmental events. These timing mechanisms, i.e., circadian clocks, include transcriptional/translational feedback loops that drive 24 h transcriptional rhythms, which underlie oscillations in protein abundance, thus mediating circadian rhythms of behavior ...
Kim, Jin A., Shim, Donghwan, Kumari, Shipra, Jung, Ha-eun, Jung, Ki-Hong, Jeong, Heesu, Kim, Woe-Yeon, Lee, Soo In, Jeong, Mi-Jeong   +8 more
openaire   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Lygus lineolaris breed:SIMRU Transcriptome or Gene expression

, 2021
Tarnished plant bug transcriptome sequencing and gene expression ...
USDA-ARS (17854919)
core  

Warmer temperature accelerates senescence by modifying the aging-dependent changes in the mosquito transcriptome, altering immunity, metabolism, and DNA repair

Immunity & Ageing
Background Global environmental temperatures are rising, which is increasing the body temperature of mosquitoes. This increase in body temperature is accelerating senescence, thereby weakening immune responses and reproductive processes, and shortening ...
Lindsay E. Martin, Jordyn S. Barr, Jean-Philippe Cartailler, Shristi Shrestha, Tania Y. Estévez-Lao, Julián F. Hillyer   +5 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Multi-ancestry gene expression models amplify transcriptome-wide association study discovery and validation

Nature Communications
Our understanding of the influence of ancestral background on genetically determined expression remains limited, especially when gene expression models are applied to studies from different or multiple populations.
Xavier Bledsoe, Nathan Watkins, Tavian Bowen-Moore, Marlisa Shaw, Ravi V. Shah, Eric R. Gamazon   +5 more
doaj   +1 more source