Results 81 to 90 of about 7,548,191 (313)

Comprehensive serial analysis of gene expression of the cervical transcriptome [PDF]

BMC Genomics, 2007
More than half of the approximately 500,000 women diagnosed with cervical cancer worldwide each year will die from this disease. Investigation of genes expressed in precancer lesions compared to those expressed in normal cervical epithelium will yield insight into the early stages of disease.
Ehlen Thomas, van Niekerk Dirk, Matisic Jasenka, Lonergan Kim M, Campbell Jennifer, Vatcher Greg, Chari Raj, Shadeo Ashleen, Miller Dianne, Follen Michele, Lam Wan L, MacAulay Calum   +11 more
openaire   +3 more sources

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Edge-weighting of gene expression graphs [PDF]

, 2009
In recent years, considerable research efforts have been directed to micro-array technologies and their role in providing simultaneous information on expression profiles for thousands of genes.
Kerr, Gráinne, Crane, Martin, DIMITRI PERRIN, HEATHER J. RUSKIN, Ruskin, Heather J., Perrin, Dimitri, MARTIN CRANE, GRAINNE KERR, Ruskin, Heather J   +8 more
core   +3 more sources

Genetics and beyond--the transcriptome of human monocytes and disease susceptibility. [PDF]

PLoS ONE, 2010
BACKGROUND: Variability of gene expression in human may link gene sequence variability and phenotypes; however, non-genetic variations, alone or in combination with genetics, may also influence expression traits and have a critical role in physiological ...
Tanja Zeller, Philipp Wild, Silke Szymczak, Maxime Rotival, Arne Schillert, Raphaele Castagne, Seraya Maouche, Marine Germain, Karl Lackner, Heidi Rossmann, Medea Eleftheriadis, Christoph R Sinning, Renate B Schnabel, Edith Lubos, Detlev Mennerich, Werner Rust, Claire Perret, Carole Proust, Viviane Nicaud, Joseph Loscalzo, Norbert Hübner, David Tregouet, Thomas Münzel, Andreas Ziegler, Laurence Tiret, Stefan Blankenberg, François Cambien   +26 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

A differential genome-wide transcriptome analysis : impact of cellular copper on complex biological processes like aging and development [PDF]

, 2012
The regulation of cellular copper homeostasis is crucial in biology. Impairments lead to severe dysfunctions and are known to affect aging and development.
Servos, Jörg, Hamann, Andrea, Andrea Hamann, Jörg Servos, Heinz D. Osiewacz (120841), Osiewacz, Heinz D., Andrea Hamann (120836), Carolin Grimm (120839), Grimm, Carolin, Jörg Servos (120834), Heinz D Osiewacz, Carolin Grimm, Osiewacz Heinz D., Servos Jörg, Grimm Carolin, Hamann Andrea   +15 more
core   +2 more sources

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Meta-analysis of retinal transcriptome profiling studies in animal models of myopia

Frontiers in Medicine
ObjectiveMyopia prevalence is increasing at alarming rates, yet the underlying mechanistic causes are not understood. Several studies have employed experimental animal models of myopia and transcriptome profiling to identify genes and pathways ...
Teele Palumaa, Teele Palumaa, Shruti Balamurugan, Machelle T. Pardue, Machelle T. Pardue, Machelle T. Pardue   +5 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Transcriptome analysis of peripheral blood from patients with rheumatoid arthritis: a systematic review

Inflammation and Regeneration, 2018
In the era of precision medicine, transcriptome analysis of whole gene expression is an essential technology. While DNA microarray has a limited dynamic range and a problem of background hybridization, RNA sequencing (RNA-seq) has a broader dynamic range
Shuji Sumitomo, Yasuo Nagafuchi, Yumi Tsuchida, Haruka Tsuchiya, Mineto Ota, Kazuyoshi Ishigaki, Akari Suzuki, Yuta Kochi, Keishi Fujio, Kazuhiko Yamamoto   +9 more
doaj   +1 more source