Results 101 to 110 of about 449,144 (306)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Transcriptome and Temporal Transcriptome Analyses in Single Cells

International Journal of Molecular Sciences
Transcriptome analysis in single cells, enabled by single-cell RNA sequencing, has become a prevalent approach in biomedical research, ranging from investigations of gene regulation to the characterization of tissue organization. Over the past decade, advances in single-cell RNA sequencing technology, including its underlying chemistry, have ...
Jun Lyu, Chongyi Chen
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A new view of transcriptome complexity and regulation through the lens of local splicing variations

eLife, 2016
Alternative splicing (AS) can critically affect gene function and disease, yet mapping splicing variations remains a challenge. Here, we propose a new approach to define and quantify mRNA splicing in units of local splicing variations (LSVs).
Jorge Vaquero-Garcia, Alejandro Barrera, Matthew R Gazzara, Juan González-Vallinas, Nicholas F Lahens, John B Hogenesch, Kristen W Lynch, Yoseph Barash   +7 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Recent insights into depression from transcriptomic analysis

Purpose: Depression is a widespread mood disorder with a high rate of relapse and chronicity that can be affected by gender, and caused by traumatic or stressful events.
Günay, Melih, Çiçekliyurt, Meliha Merve, Melih Günay, Meliha M. Çiçekliyurt   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression

, 2022
Numerous studies have been performed over the last decade to exploit the complexity of genomic and transcriptomic lesions driving the initiation of acute myeloid leukemia (AML). These studies have helped improve risk classification and treatment options.
Krogh Herlin, Morten, Munthe-Kaas, Monica Cheng,, Norgren, N., Abrahamsson, Jonas, Mayrhofer, Markus,, Holmfeldt, Linda,, Skaftason, Aron,, Palle, J., Garbulowski, M., Mayrhofer, M., Skaftason, Aron, Stratmann, Svea,, Garbulowski, Mateusz,, Norgren, Nina, Munthe-Kaas, Monica Cheng, Herlin, Morten Krogh,, Tamm, Katja Pokrovskaja,, Herlin, Morten Krogh, Stratmann, S., Cheng Munthe-Kaas, Monica,, Tamm, K. P., Hoglund, M., Sundström, Christer, Jahnukainen, Kirsi, Krogh Herlin, Morten,, Norgren, Nina,, Mayrhofer, Markus, Sun, J., Sun, Jitong, Komorowski, Jan,, Holmfeldt, L., Höglund, Martin,, Komorowski, J., Zeller, Bernward, Höglund, Martin, Cavelier, Lucia,, Yones, Sara A.,, Sundstrom, C., Zeller, B., Herlin, M. K., Komorowski, Jan, Eriksson, Anna,, Tamm, Katja Pokrovskaja, Cavelier, L., Yones, S. A., Palle, Josefine,, Pokrovskaja Tamm, Katja, Garbulowski, Mateusz, Abrahamsson, Jonas,, Pokrovskaja Tamm, Katja,, Cavelier, Lucia, Jahnukainen, K., Stratmann, Svea, Cheng Munthe-Kaas, Monica, Zeller, Bernward,, Munthe-Kaas, M. C., Yones, Sara A., Eriksson, Anna, Holmfeldt, Linda, Skaftason, A., Palle, Josefine, Eriksson, A., Sun, Jitong,, Sundström, Christer,, Jahnukainen, Kirsi,   +64 more
core   +1 more source