Results 51 to 60 of about 475,601 (307)

Transcriptomic Profiling of iPS Cell-Derived Hepatocyte-like Cells Reveals Their Close Similarity to Primary Liver Hepatocytes

Cells
Human-induced pluripotent stem cell (iPSC)-derived hepatocyte-like cells (HLCs) have been shown to be useful for the development of cell-based regenerative strategies and for modelling drug discovery.
Saqlain Suleman, Sharmin Alhaque, Andrew Guo, Aaron Zhang, Serena Fawaz, Stefany Perera, Mohammad S. Khalifa, Hassan Rashidi, David C. Hay, Michael Themis   +9 more
doaj   +1 more source

Integrated Excitatory/Inhibitory Imbalance and Transcriptomic Analysis Reveals the Association between Dysregulated Synaptic Genes and Anesthetic-Induced Cognitive Dysfunction

Cells, 2022
Emerging evidence from human epidemiologic and animal studies has demonstrated that developmental anesthesia neurotoxicity could cause long-term cognitive deficits and behavioral problems. However, the underlying mechanisms remain largely unknown.
Yasheng Yan, Sarah Logan, Xiaojie Liu, Bixuan Chen, Congshan Jiang, Thiago Arzua, Ramani Ramchandran, Qing-song Liu, Xiaowen Bai   +8 more
doaj   +1 more source

Evolution: The Plastic Transcriptome [PDF]

Current Biology, 2006
Studies across a wide range of species point to a surprising degree of plasticity in the transcriptional states that organisms can adopt, suggesting that organisms often respond to environmental challenges through wholesale reprogramming of their gene expression.
openaire   +5 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Transcriptomic Survey of How Acetate Addition Affected the Growth in Nannochloropsis oceanica (Suda & Miyashita) R. E. Lee

Life
Nannochloropsis oceanica (Suda & Miyashita) R. E. Lee holds considerable potential for the production of high-value compounds, including pigments, lipids, and polyunsaturated fatty acids.
Yikai Wu, Han Zhu, Hang Su, Li Wei
doaj   +1 more source

Global Gene-expression Analysis of the Response of Salmonella Enteritidis to Egg White Exposure Reveals Multiple Egg White-imposed Stress Responses

Frontiers in Microbiology, 2017
Chicken egg white protects the embryo from bacterial invaders by presenting an assortment of antagonistic activities that combine together to both kill and inhibit growth. The key features of the egg white anti-bacterial system are iron restriction, high
Florence Baron, Florence Baron, Sylvie Bonnassie, Sylvie Bonnassie, Sylvie Bonnassie, Mariah Alabdeh, Mariah Alabdeh, Marie-Françoise Cochet, Marie-Françoise Cochet, Françoise Nau, Françoise Nau, Catherine Guérin-Dubiard, Catherine Guérin-Dubiard, Michel Gautier, Michel Gautier, Simon C. Andrews, Sophie Jan, Sophie Jan   +17 more
doaj   +1 more source

Identification of Transcriptome Biomarkers for Severe COVID-19 with Machine Learning Methods

Biomolecules, 2022
The rapid spread of COVID-19 has become a major concern for people’s lives and health all around the world. COVID-19 patients in various phases and severity require individualized treatment given that different patients may develop different symptoms. We
Xiaohong Li, Xianchao Zhou, Shijian Ding, Lei Chen, Kaiyan Feng, Hao Li, Tao Huang, Yu-Dong Cai   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Integrated transcriptomic and metabolomic analyses reveal a novel mechanism of resistance to Colletotrichum fructicola in pear

Journal of Integrative Agriculture
Pear anthracnose, caused by Colletotrichum fructicola, is a devastating disease that seriously affects most pear varieties, compromising their yield and quality. However, effective control of this pathogen is lacking.
Xiaomei Tang, Yue Wang, Yuqing Guo, Luoluo Xie, Wei Song, Ziwen Xiao, Ruichang Yin, Zhe Ye, Xueqiu Sun, Wenming Wang, Lun Liu, Zhenfeng Ye, Zhenghui Gao, Bing Jia   +13 more
doaj   +1 more source

Transcriptomic analysis of Sporisorium reilianum in response to the strigolactone analogue GR24

Phytopathologia Mediterranea, 2012
A suppression subtractive hybridization (SSH) approach was used to generate cDNA libraries representing genes differentially expressed in the haploid cells of the maize head smut pathogen Sporisorium reilianum exposed to GR24, a strigolactone analogue ...
Seyed SABBAGH, Mahta MAZAHERI, Naser PANJEHKEH, Mohammad SALARI   +3 more
doaj   +1 more source