Results 71 to 80 of about 475,601 (307)

Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies

Frontiers in Pharmacology, 2018
Chronic lung disease remains the primary cause of mortality in cystic fibrosis (CF). Growing evidence suggests respiratory viral infections are often more severe in CF compared to healthy peers and contributes to pulmonary exacerbations (PEx) and ...
Kak-Ming Ling, Kak-Ming Ling, Luke W. Garratt, Timo Lassmann, Stephen M. Stick, Stephen M. Stick, Stephen M. Stick, Stephen M. Stick, Anthony Kicic, Anthony Kicic, Anthony Kicic, Anthony Kicic, Anthony Kicic, WAERP, AusREC, AusREC, AusREC, Australian Respiratory Early Surveillance Team for Cystic Fibrosis, Australian Respiratory Early Surveillance Team for Cystic Fibrosis, Australian Respiratory Early Surveillance Team for Cystic Fibrosis, Australian Respiratory Early Surveillance Team for Cystic Fibrosis   +20 more
doaj   +1 more source

Transcriptomics and metabolomics changes triggered by exogenous 6-benzylaminopurine in relieving epicotyl dormancy of Polygonatum cyrtonema Hua seeds

Frontiers in Plant Science, 2022
Polygonatum cyrtonema Hua is one of the most useful herbs in traditional Chinese medicine and widely used in medicinal and edible perennial plant. However, the seeds have the characteristics of epicotyl dormancy.
Wenwu Zhang, Long Xia, Fulei Peng, Chenyu Song, Muhammad Aamir Manzoor, Yongping Cai, Qing Jin   +6 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Transcriptomic and Lipidomic Analysis Reveals the Regulatory Network of Lipid Metabolism in Cannabis sativa

Foods
Hemp possesses significant healthcare value due to its rich composition of unsaturated fatty acids and a distinctive golden ratio of linoleic acid to α-linolenic acid.
Bowei Yan, Chuanyi Chang, Yue Sui, Nan Zheng, Yuyan Fang, Yuanye Zhang, Ming Zhang, Dan He, Liguo Zhang   +8 more
doaj   +1 more source

Comprehensive Analysis of Aspergillus nidulans PKA Phosphorylome Identifies a Novel Mode of CreA Regulation

mBio, 2019
In filamentous fungi, an important kinase responsible for adaptation to changes in available nutrients is cyclic AMP (cAMP)-dependent protein kinase (protein kinase A [PKA]).
Liliane F. C. Ribeiro, Cynthia Chelius, Karthik R. Boppidi, Nisha S. Naik, Simin Hossain, Jessica J. J. Ramsey, Jyothi Kumar, Lucas F. Ribeiro, Marc Ostermeier, Bao Tran, Young Ah Goo, Leandro J. de Assis, Mevlut Ulas, Ozgur Bayram, Gustavo H. Goldman, Stephen Lincoln, Ranjan Srivastava, Steven D. Harris, Mark R. Marten   +18 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The Effects of Nisin-Producing Lactococcus lactis Strain Used as Probiotic on Gilthead Sea Bream (Sparus aurata) Growth, Gut Microbiota, and Transcriptional Response

Frontiers in Marine Science, 2021
The present research tested the effects of dietary nisin-producing Lactococcus lactis on growth performance, feed utilization, intestinal morphology, transcriptional response, and microbiota in gilthead sea bream (Sparus aurata).
Federico Moroni, Fernando Naya-Català, M. Carla Piazzon, Simona Rimoldi, Josep Calduch-Giner, Alberto Giardini, Inés Martínez, Fabio Brambilla, Jaume Pérez-Sánchez, Genciana Terova   +9 more
doaj   +1 more source

Decisions involved in transcriptomic data preprocessing.

, 2019
Decisions involved in transcriptomic data preprocessing.
Anne Richelle (6589178), Chintan Joshi (7010672), Nathan E. Lewis (599027)   +2 more
core   +1 more source

Transcriptomic data used for the meta-analysis.

, 2021
The datasets used derive from both individuals with DS and DS mouse models, and span different tissues, sex, ages and treatment effects. a) Barplot showing the number of transcriptomic datasets for each tissue in Mus Musculus (red) and Homo sapiens ...
Ilario De Toma (3251964), Cesar Sierra (11486010), Mara Dierssen (51655)   +2 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source