Results 121 to 130 of about 299,908 (313)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Robust HPV‐16 Detection Workflow for Formalin‐Fixed Cancer Tissue and Its Application for Oral Squamous Cell Carcinoma

Cancer Medicine
Background Virus‐related cancers are malignancies caused by specific viruses, such as human papillomavirus (HPV), hepatitis B virus, and human T‐cell leukemia virus, contributing significantly to the global cancer burden through persistent infection and ...
Shizuka Morodomi, Akiyuki Hirosue, Akhinur Rahman, Kyotaro Nohata, Misaki Matsuo, Omnia Reda, Samiul Alam Rajib, Haruki Saito, Hiroki Takeda, Ryoji Yoshida, Masafumi Nakamoto, Masatoshi Hirayama, Kenta Kawahara, Mitsuyoshi Takatori, Yorihisa Orita, Hideki Nakayama, Yorifumi Satou   +16 more
doaj   +1 more source

Transcriptomic Signature of the SHATTERPROOF2 Expression Domain Reveals the Meristematic Nature of Arabidopsis Gynoecial Medial Domain [PDF]

, 2016
Gonzalo Villarino, Qiwen Hu, Silvia Manrique, Miguel A. Flores‐Vergara, Bhupinder Sehra, Linda M. Robles, Javier Brumós, Anna N. Stepanova, Lucia Colombo, Eva Sundberg, Steffen Heber, Robert G. Franks   +11 more
openalex   +1 more source

In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19

, 2022
SeyedehMozhdeh Mirmohammadi, Anvarsadat Kianmehr, Amir Sabbaghian, Alireza Mohebbi, Hamid Shahbazmohammadi, Mehdi Sheykharabi, Zahra Bazzi   +6 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Finding undetected protein associations in cell signaling by belief propagation

, 2011
External information propagates in the cell mainly through signaling cascades and transcriptional activation, allowing it to react to a wide spectrum of environmental changes.
A. Braunstein, A. Dagkessamanskaia, Aronova, Bashor, Bayati, Benayoun, Burkholder, C. Borgs, Dickson, Guldener, Huang, J. Chayes, J.- M. Francois, Jenness, King, Kuranda, Locasale, M. Bailly-Bechet, Miyake, Nickell, Pei, R. Zecchina, Roberts, Scott, Soufi, Spode, Thattai, Travers, Xenarios, Yosef, Zheng   +30 more
core   +3 more sources

Ecological transcriptomics – a non‐lethal sampling approach for endangered fire salamanders [PDF]

, 2015
Till Czypionka, Tamar Krugman, Janine Altmüller, Leon Blaustein, Sebastian Steinfartz, Alan R. Templeton, Arne W. Nolte   +6 more
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source