Results 171 to 180 of about 398,969 (379)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The dawn of spatiotemporal transcriptomics

Biomedical Analysis
Gene expression of cells in the tissues is a heterogeneous and dynamic program across space and time. Spatiotemporal transcriptomics technologies have emerged as transforming tools to dissect the spatiotemporal patterns of gene regulation in diverse ...
Siying Wang, Shichao Lin, Chaoyong Yang
doaj   +1 more source

Finding undetected protein associations in cell signaling by belief propagation

, 2011
External information propagates in the cell mainly through signaling cascades and transcriptional activation, allowing it to react to a wide spectrum of environmental changes.
A. Braunstein, A. Dagkessamanskaia, Aronova, Bashor, Bayati, Benayoun, Burkholder, C. Borgs, Dickson, Guldener, Huang, J. Chayes, J.- M. Francois, Jenness, King, Kuranda, Locasale, M. Bailly-Bechet, Miyake, Nickell, Pei, R. Zecchina, Roberts, Scott, Soufi, Spode, Thattai, Travers, Xenarios, Yosef, Zheng   +30 more
core   +3 more sources

Derivation and Comparative Assessment of Retinal Pigment Epithelium from Human Embryonic Stem Cells Using Transcriptomics [PDF]

, 2004
Irina Klimanskaya, Jason Hipp, Kourous A. Rezai, Michael West, Anthony Atala, Robert Lanza   +5 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

IRF8 and MAFB drive distinct transcriptional machineries in different resident macrophages of the central nervous system

Communications Biology
The central nervous system (CNS) includes anatomically distinct macrophage populations including parenchyma microglia and CNS-associated macrophages (CAMs) localized at the interfaces like meninges and perivascular space, which play specialized roles for
Ayato Yamasaki, Iroha Imanishi, Kaori Tanaka, Yasuyuki Ohkawa, Makoto Tsuda, Takahiro Masuda   +5 more
doaj   +1 more source

Digital transcriptomics: A flavour of SAGE [PDF]

, 2004
Kåre Lehmann Nielsen, Jeppe Emmersen, Karen G. Welinder   +2 more
openalex   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Erratum to: Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression [PDF]

, 2004
Martı́n C. Abba, Jeffery Drake, Kathleen A. Hawkins, Yuhui Hu, Hongxia Sun, Cinitia Notcovich, Sally Gaddis, Ayşegül A. Şahin, Keith Baggerly, C. Marcelo Aldaz   +9 more
openalex   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source