Results 171 to 180 of about 299,908 (313)

Transcriptomics similarities between Alzheimer’s Disease and Cardiovascular Disease [PDF]

, 2023
Lucas Uglione Da Ros, Marco Antônio De Bastiani, Lara Willers Lobato, Eduardo R. Zimmer   +3 more
openalex   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Comparative Transcriptomics Reveals How Wheat Responds to Infection by Zymoseptoria tritici [PDF]

, 2017
Xin Ma, Beat Keller, Bruce A. McDonald, Javier Palma‐Guerrero, Thomas Wicker   +4 more
openalex   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Dynamic transcriptomic responses to divergent acute exercise stimuli in young adults

, 2023
Kaleen M. Lavin, Zachary Graham, Jeremy S. McAdam, Samia M. O’Bryan, Devin Drummer, Margaret B. Bell, Christian Kelley, Manoel E. Lixandrão, Brandon Peoples, S. Craig Tuggle, Regina Seay, Kendall Van Keuren‐Jensen, Matthew J. Huentelman, Patrick Pirrotte, Rebecca Reiman, Eric Alsop, Elizabeth Hutchins, Jerry Antone, Anna Bonfitto, Bessie Meechoovet, Joanna Palade, Joshua S. Talboom, Amber Sullivan, Inmaculada Aban, Kalyani Peri, Timothy J. Broderick, Marcas M. Bamman   +26 more
openalex   +2 more sources

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, EarlyView.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a possible key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure

, 2022
Muhammad Imran, Frédéric Chalmel, Odile Sergent, Bertrand Evrard, Hélène Le Mentec, Antoine Legrand, Aurélien Dupont, Maëlle Bescher, Simon Bucher, Bernard Fromenty, Laurence Huc, Lydie Sparfel, Dominique Lagadic‐Gossmann, Normand Podechard   +13 more
openalex   +2 more sources

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

scVAR: integrating genomics and transcriptomics from single-cell RNA-seq -insights from leukemia case studies. [PDF]

Front Genet
Celli L, Manessi S, Barcella M, Merelli I.   +3 more
europepmc   +1 more source

In Silico Transcriptomic Analysis of Wound-Healing-Associated Genes in Malignant Pleural Mesothelioma [PDF]

, 2019
Erasmia Rouka, Eleftherios Beltsios, Dimos Goundaroulis, George D. Vavougios, Evgeniy I. Solenov, Chrissi Hatzoglou, Konstantinos I. Gourgoulianis, Sotirios G. Zarogiannis   +7 more
openalex   +1 more source