Results 241 to 250 of about 320,395 (368)

Hydrogel‐Mediated Preservation of Live Tumor Explants for Drug Development in Peritoneal Metastases

Advanced Materials, EarlyView.
This study presents a hyaluronan‐based hydrogel platform preserving the native tumor microenvironment (morphology, tissue composition, histology) of patient‐derived explants from peritoneal metastases, enabling clinically relevant drug screening. Hydrogel properties such as stiffness and degradation are crucial for longer‐term histoculture.
Kenny Zhuoran Wu, Rockie Haiyao Ding, Zixuan Zhao, Clara Yieh Lin Chong, Ruochii You, Hengjia Zhou, Dong Hua Seah, Wei Qiang Leow, Hong Kit Lim, Sukanya Shyamasundar, Kanishka Fernando, Fathima Farzana Kuthubudeen, Gillian Ng, Chor Yong Tay, Narayanan Gopalakrishna Iyer, Chin‐Ann Johnny Ong, Eliza Li Shan Fong   +16 more
wiley   +1 more source

Multiomics in Renal Cell Carcinoma: Current Landscape and Future Directions for Precision Medicine. [PDF]

Curr Urol Rep
Gavi F, Sighinolfi MC, Pallotta G, Assumma S, Panio E, Fettucciari D, Silvestri A, Russo P, Bientinesi R, Foschi N, Turri F, Carbonara U, Ciccarese C, Iacovelli R, Nero C, Rocco B.   +15 more
europepmc   +1 more source

Transcript Identification Using Arrayed Hydrogels With TrapFISH

Advanced Materials Technologies, EarlyView.
TrapFISH is a novel method for high‐throughput single‐cell transcriptomics. It embeds cells in hyaluronic acid hydrogel beads and uses probe hybridization to quantify custom gene panels. By arraying hydrogels in microfluidic devices, cell barcoding is removed, enhancing scalability for studying cellular heterogeneity and rare cell states by targeting ...
David B. Morse, Zenon Toprakcioglu, Akhila Denduluri‐Marthi, James D. Brenton, Craig J. Thomas, Tuomas P. J. Knowles   +5 more
wiley   +1 more source

Spatial transcriptomics herald a new era of transcriptome research

Clinical and Translational Medicine, 2023
Dominik Saul, Robyn Laura Kosinsky
openaire   +3 more sources

m2ST: dual multi-scale graph clustering for spatially resolved transcriptomics. [PDF]

Bioinformatics
Zhang W, Zhang Z, Yang H, Zhang T, Jiang S, Qiao N, Deng Z, Pan X, Shen HB, Yu DJ, Wang S.   +10 more
europepmc   +1 more source

SuperSAGE [PDF]

, 2005
Ito, A., Kahl, G., Kruger, D., Matsumura, H., Reuter, M., Saitoh, H., Terauchi, R., Winter, P.   +7 more
core  

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Highly sensitive spatial transcriptomics at near-cellular resolution with Slide-seqV2

Nature Biotechnology, 2020
Robert R. Stickels, Evan Murray, Pawan Kumar, Jilong Li, Jamie L. Marshall, Daniela J. Di Bella, P. Arlotta, Evan Z. Macosko, Fei Chen   +8 more
semanticscholar   +1 more source

Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice

Advanced Science, EarlyView.
This study opens a new avenue for safeguarding cognition and muscle health, averting disability in older age, and treating age‐related pathologies through lecithin supplementation. It serves as a promising nonpharmacological intervention for the crosstalk of muscle and cognition.
Xianyun Wang, Dajun Li, Xiao Ying Li, Weizhao Lu, Huini Ding, Chengyan Qi, Xuan Wang, Jing Shen, Yafei Chi, Tiantian Li, Michelle M. Dunk, Yu An, Hongmei Huang, Kang Yu, Weili Xu, Rong Xiao, Yuandi Xi   +16 more
wiley   +1 more source

Untargeted metabolomics and transcriptomics joint analysis of the effects of polystyrene nanoplastics on lipid metabolism in the mouse liver. [PDF]

Lipids Health Dis
Chen L, Sui G, Wu J, Li N, Zhang Z, Du Y, Lü M, Yan X, Pan G, Jia L.   +9 more
europepmc   +1 more source