Results 291 to 300 of about 398,969 (379)

Heterogeneity Landscape of Circulating Tumor Cells in Clinical Utility

Advanced Therapeutics, EarlyView.
This study reports the heterogeneity spectrum of circulating tumor cells. The factors involved in the spectrum promote CTCs to overcome barriers in the metastatic cascade but impact the clinical outcome of cancer patients. In summary, the heterogeneities in association with CTCs ultimately reduce patient survival and facilitate increasing mortality of ...
Md Kowsar Alam, Lu Yanjun, Bee Luan Khoo, Tongxu Si, Heng Zou, Mengsu Yang   +5 more
wiley   +1 more source

Transcriptomic blueprints [PDF]

Nature Reviews Genetics, 2017
openaire   +3 more sources

Underpinning regions associated with nitrogen use efficiency in Brassica juncea L. Czern: using associative transcriptomics approach. [PDF]

BMC Plant Biol
Awasthi A, Rialch I, Kaur H, Sharma S, Harper AL, Havlickova L, Bancroft I, Banga SS.   +7 more
europepmc   +1 more source

Phenotypic and Transcriptomic Changes Associated With Potato Autopolyploidization

, 2007
Robert M. Stupar, Pudota B. Bhaskar, Brian S. Yandell, Willem Albert Rensink, Amy Hart, Shu Ouyang, Richard E. Veilleux, James S. Busse, Robert J. Erhardt, C. Robin Buell, Jiming Jiang   +10 more
openalex   +1 more source

Gallium β‐Cyclodextrin Nanoparticles Containing both Gallium Protoporphyrin and Gallium Nitrate Exhibit Antimicrobial Activity against Nontuberculous Mycobacteria in Vitro and in Vivo

Advanced Therapeutics, EarlyView.
Cyclodextrin nanoparticle containing both Ga(NO3)3 and GaPP is synthesized and tested against non‐tuberculous mycobacteria (NTM). The in vivo efficacy of the nanoparticle therapy is additionally tested by treating pulmonary NTM infections in mice and observed much greater effectiveness in bacterial clearance and survival of mice.
Seoung‐ryoung Choi, Bradley E. Britigan, Prabagaran Narayanasamy   +2 more
wiley   +1 more source

PCK1 and ALDH1A1 are identified as biomarkers for inherent drug resistance in hepatocellular carcinoma. [PDF]

Discov Oncol
Chen W, Zhou C, Liu G, Wang X, Yi Y, Xu Y, Qiu S.   +6 more
europepmc   +1 more source

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Advanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu, Jingyi Liu, Wei Qin, Chengsheng Ding, Zhenghao Cai, Duohuo Shu, Hao Zhong, Yanyan Hu, Mengqin Yu, Leqi Zhou, Jianwen Li, Minhua Zheng, Bin Li, Sen Zhang, Xiao Yang, Bo Feng   +15 more
wiley   +1 more source

Single-cell atlas of human pediatric liver reveals age-related hepatic gene signatures. [PDF]

Hepatol Commun
Edgar RD, Nakib D, Camat D, Chung S, Lumanto P, Atif J, Perciani CT, Ma XZ, Thoeni C, Selvakumaran N, Manuel J, Sayed B, Huysentruyt K, Ricciuto A, McGilvray I, Avitzur Y, Bader GD, MacParland SA.   +17 more
europepmc   +1 more source

NAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR

Advanced Science, EarlyView.
Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou, Xi Xiong, Jialong Hou, Qi Duan, Yi Zheng, Tao Jiang, Jiani Huang, Haijun He, Jiaxue Xu, Keke Chen, Wenwen Wang, Jinlai Cai, Jingjing Qian, Huijun Chen, Weihong Song, XinShi Wang, Chenglong Xie   +16 more
wiley   +1 more source

Dissecting microbial communities with single-cell transcriptome analysis. [PDF]

Science
Pountain AW, Yanai I.
europepmc   +1 more source