Results 101 to 110 of about 94,046 (310)

Evaluating Response to High-Dose 13.3 mg/24 h Rivastigmine Patch in Patients with Severe Alzheimer's Disease [PDF]

, 2015
AIMS: To identify factors predicting improvement/stabilization on the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC) and investigate whether early treatment responses can predict long-term outcomes, during a ...
Farlow, Martin R., Islam, M. Zahur, Meng, Xiangyi, Sadowsky, Carl H., Velting, Drew M.   +4 more
core   +1 more source

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men

Advanced Science, EarlyView.
In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...
Grith Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog, Eugenia Migliavacca, Sonia Karaz, Elham Pazirandeh‐Micol, Odd E. Johansen, Leonidas G. Karagounis, Bjørk W. Helge, William Hagemann, Michael Kjaer, Jerome N. Feige, Pascal Stuelsatz, Abigail L. Mackey   +14 more
wiley   +1 more source

Globular and Fibrous Proteins Modified with Deep Eutectic Solvents: Materials for Drug Delivery

Molecules, 2019
Proteinaceous materials have numerous structures, many of which aid in the roles they perform. Some need to impart strength while others need elasticity or toughness.
Wanwan Qu, Riina Häkkinen, Jack Allen, Carmine D’Agostino, Andrew P. Abbott   +4 more
doaj   +1 more source

PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu, Shule Zhang, Ruofan Du, Lina Kang, Guodong Zhao, Xue Bao, Haochi Yang, Ziqing Xie, Tianyu He, Huiyong Sun, Haiping Hao, Lijuan Cao   +11 more
wiley   +1 more source

Iontophoretic and Microneedle Mediated Transdermal Delivery of Glycopyrrolate

Pharmaceutics, 2014
Purpose: The objective of this study was to investigate the use of iontophoresis, soluble microneedles and their combination for the transdermal delivery of glycopyrrolate.
Meera Gujjar, Ajay K. Banga
doaj   +1 more source

Metabolic, inflammatory and haemostatic effects of a low-dose continuous combined HRT in women with type 2 diabetes: potentially safer with respect to vascular risk? [PDF]

, 2003
BACKGROUND Conventional hormone replacement therapy (HRT) containing conjugated equine oestrogen (CEE) and medroxyprogesterone acetate (MPA) increases triglyceride, C- reactive protein (CRP) and coagulation Factor VII concentrations, potentially ...
Alan J. Jaap, Andersen, Anderson, Ann Rumley, Anne Kelly, Brussard, Cushman, Dichtl, Ferrara, Gordon D. Lowe, Gornstein, Herrington, Hokanson, Hulley, Ian A. Greer, John R. Petrie, Joyce McKenzie, Kanaya, Kenneth Paterson, Knopp, Koh, Kroon, Kroon, Lokkegaard, Lowe, Lowe, Lowe, Lynne Crawford, Manning, Meade, Naveed Sattar, Perera, Petitti, Pradhan, Rapp, Ridker, Ridker, Rossouw, Sattar, Sattar, Stephen Gallacher, Stork, Van Baal, Van Baal, Vehkavaara, Woodward, Zanger   +46 more
core   +1 more source

Wearable Battery‐Free Electrotherapy of Smartsensors for Wound Healthcare

Advanced Science, EarlyView.
Herein, we propose a simple strategy for integrating battery‐free electrotherapy wound dressings with wound sensors. Solid‐state supercapacitors constructed by PMAB with cross‐linked interpenetrating network provide energy for electrotherapy. Meanwhile, excellent mechanical sensing performance of wound dressing was used for wound assessment.
Wenrui Zhang, Qian Lin, Jiancheng Zhang, Hao Mo, Wencheng Li, Yicheng Hu, Hongting Ma, Dan Zhao, Hongnv Yu, Nan Zhu   +9 more
wiley   +1 more source

Wearable Enzymatic Alcohol Biosensor

Sensors, 2019
Transdermal alcohol biosensors have the ability to detect the alcohol that emanates from the bloodstream and diffuses through the skin. However, previous biosensors have suffered from long-term fouling of the sensor element and drift in the resulting ...
Bob Lansdorp, William Ramsay, Rashad Hamid, Evan Strenk   +3 more
doaj   +1 more source

A Review on Catalytic Nanostructured Electrodes for Wearable and Implantable Abiotic Glucose Fuel Cells

Advanced Science, EarlyView.
This review identifies current and future directions in abiotic nanostructured catalysts to develop reliable and sustainable glucose fuel cells to power the next generation of bioelectronic devices. ABSTRACT The global rise in incidence of chronic diseases has led to the demand for innovative solutions that help patients manage their conditions with ...
Asghar Niyazi, Hannah S. Leese, Benjamin Metcalfe, Mirella Di Lorenzo   +3 more
wiley   +1 more source

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

Advanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Melissa A. Willman, Alexander Rabassa, Ashley L. Joubert, Tommaso Bo, Letizia Franco, Marzia Conte, Ana L. Anaya‐García, Gabrielle E. Rome, Rim Ouni, Henry J. Seaborne, Camden A. Caffey, Dora M. Berman, Junjun Zheng, Jesus Paez‐Mayorga, Corrine Ying Xuan Chua, Shu Hsia Chen, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source