Results 281 to 290 of about 1,640,128 (340)
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Annual Review of Medicine, 1988
Transdermal drug delivery involves the continuous administration of therapeutic molecules through the skin. It has the advantage of maintaining constant drug plasma levels and improving patient compliance. Compared to the oral route, losses in bioavailability due to first-pass liver metabolism are reduced. This paper describes the theory of transdermal
L, Brown, R, Langer
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Transdermal drug delivery involves the continuous administration of therapeutic molecules through the skin. It has the advantage of maintaining constant drug plasma levels and improving patient compliance. Compared to the oral route, losses in bioavailability due to first-pass liver metabolism are reduced. This paper describes the theory of transdermal
L, Brown, R, Langer
openaire +2 more sources
ACS Applied Materials and Interfaces, 2021
Since injection administration for diabetes is invasive, it is important to develop an effective transdermal method for insulin. However, transdermal delivery remains challenging owing to the strong barrier function of the stratum corneum (SC) of the ...
Md. Rafiqul Islam +5 more
semanticscholar +1 more source
Since injection administration for diabetes is invasive, it is important to develop an effective transdermal method for insulin. However, transdermal delivery remains challenging owing to the strong barrier function of the stratum corneum (SC) of the ...
Md. Rafiqul Islam +5 more
semanticscholar +1 more source
Transdermal drug delivery devices
Clinics in Dermatology, 1989Abstract The concept of transdermal delivery is not new, but until recently, its therapeutic application was restricted to creams and ointments which are messy and difficult to apply uniformly to ensure reproducible dosing. In the late 1970s, technology was developed that permitted the construction of multicomponent devices embodying the ability to ...
P W, Ledger, K C, Nichols
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Transdermal Delivery of Testosterone*
The Journal of Clinical Endocrinology & Metabolism, 1987We administered testosterone transdermally to six hypogonadal men by applying a thin flexible polymeric membrane containing testosterone to the scrotum. Each man wore a placebo membrane and three doses (5, 10, and 15 mg) of testosterone-containing membranes for 22 h/day. Each dose was worn for 1 week, and one dose was worn a second week.
J C, Findlay, V A, Place, P J, Snyder
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Journal of Controlled Release
Gene delivery has revolutionized conventional medical approaches to vaccination, cancer, and autoimmune diseases. However, current gene delivery methods are limited to either intravenous administration or direct local injections, failing to achieve well biosafety, tissue targeting, drug retention, and transfection efficiency for desired therapeutic ...
Wentao, Zhang +5 more
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Gene delivery has revolutionized conventional medical approaches to vaccination, cancer, and autoimmune diseases. However, current gene delivery methods are limited to either intravenous administration or direct local injections, failing to achieve well biosafety, tissue targeting, drug retention, and transfection efficiency for desired therapeutic ...
Wentao, Zhang +5 more
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A Review on Transdermal Drug Delivery Systems
International Journal of Science Architecture Technology and EnvironmentR ecently delivery of drugs through the skin is being a challenging area for research because of barrier properties exhibit by the outermost layer of skin stratum corneum. The transdermal drug delivery system has offers significant clinical benefits over
Mahesh Prakashrao Choudhari
semanticscholar +1 more source
2022
Being the largest and most accessible organ, the skin is an attractive target for drug delivery. However, the efficient barrier function of the stratum corneum presents a considerable challenge to the delivery of therapeutic into and across the skin. Nevertheless, years of research in the area of skin permeation culminated with the regulatory approval ...
Qonita Kurnia Anjani +3 more
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Being the largest and most accessible organ, the skin is an attractive target for drug delivery. However, the efficient barrier function of the stratum corneum presents a considerable challenge to the delivery of therapeutic into and across the skin. Nevertheless, years of research in the area of skin permeation culminated with the regulatory approval ...
Qonita Kurnia Anjani +3 more
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Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system
Drug DeliveryBurn injuries are prevalent and life-threatening forms that contribute significantly to mortality rates due to associated wound infections. The management of burn wounds presents substantial challenges.
MeeiChyn Goh +4 more
semanticscholar +1 more source
Transdermal delivery of levonorgestrel
Medicinal Research Reviews, 1991This review of the research and development of transdermal delivery systems for levonorgestrel and combinations of levonorgestrel and estrogens also contains explanatory material on skin structure and absorption of drugs by diffusion and partition permeability and use of enhancers to facilitate absorption use of pro-drugs and derivatives and cutaneous ...
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Transdermal delivery of steroids
Contraception, 1989The advantages of delivering drugs through the skin for systemic therapy have been widely recognized and represent a growing sector in drug development. Transdermal delivery of steroids is also a rapidly expanding field and in various clinical situations where hormonal replacement therapy is needed this route of administration is a real breakthrough ...
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