Results 111 to 120 of about 20,575,683 (284)

Review on Solubility enhancement of Metoclopramide base by solid dispersion technique for Transdermal drug delivery system [PDF]

, 2019
Modern drug discovery has led to the development of drug molecules that exhibit high lipophilicity and poor water solubility, which leads to problematic bioavailability.
Sengupta, Riyanka, Sarkar, Pintu, Paul, Moumita, Datta, Prabir Kumar, Mukhopadhyay, Goutam   +4 more
core   +1 more source

Gallic-Acid-Loaded PLGA Nanoparticles: A Promising Transdermal Drug Delivery System with Antioxidant and Antimicrobial Agents. [PDF]

Pharmaceuticals (Basel), 2023
Aldawsari MF, Alkholifi FK, Foudah AI, Alqarni MH, Alam A, Salkini MA, Sweilam SH.   +6 more
europepmc   +1 more source

Magnetic Thermal Ablation Combined with Temporally Coordinated CpG Immunotherapy Promotes cDC1‐Dependent Immune Priming in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Novel PLA@Fe3O4 magnetic microspheres were developed for transarterial magnetic hyperthermia ablation (MTA) of hepatocellular carcinoma. While destroying local tumors and inducing immunogenic cell death (ICD), MTA combined with early CpG adjuvant administration significantly promotes cDC1‐dependent immune priming. This synergistic mechanism effectively
Jiakun Yang, Nailin Yang, Shuangshuang Ji, Siping Meng, Di Wang, Wenjun Liang, Xuming Bai, Yong Jin, Xingwei Sun   +8 more
wiley   +1 more source

A Novel Integrated Transdermal Drug Delivery System with Micropump and Microneedle Made from Polymers. [PDF]

Micromachines (Basel), 2022
Attiguppe AP, Chatterjee D, DasGupta A.
europepmc   +1 more source

A REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM

, 2018
Recently delivery of drugs through the skin is being a challenging area for research because of barrier properties exhibit by the outermost layer of skin stratum corneum.
Prof. Madhuri T. Deshmukh, Harshada A. Lawale *, Prof. R.V. Shete, Prof. R.S. Solunke
core   +1 more source

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

Advanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang, Hongzhao Qi, Yanyan Yang, Feng Wang, Tiantian Han, Yanbei Lei, Xiaolu Li, Zhibin Wang, Hua Qu, Tao Yu, Pin Sun   +10 more
wiley   +1 more source

Losartan Potassium and Verapamil Hydrochloride Compound Transdermal Drug Delivery System: Formulation and Characterization. [PDF]

Int J Mol Sci, 2022
Chen YS, Sun YY, Qin ZC, Zhang SY, Chen WB, Liu YQ.   +5 more
europepmc   +1 more source

ETHOSOMES: A NOVEL TRANSDERMAL DRUG DELIVERY SYSTEM [PDF]

, 2014
Skin acts as a major target as well as a principal barrier for topical/transdermal drug delivery. Despite the many advantages of this system, the major obstacle is the low diffusion rate of drugs across the stratum corneum.
Dutt, Rajeswar, KUMAR.CH, ANANDA
core   +1 more source

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

Advanced Science, EarlyView.
Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li, Chengwei Zhang, Xinying Yu, Shuang Yao, Yiting Lai, Xiaozhu Sun, Yao Zhao, Xiaoyu Lan, Tingting Hu, Wenjin Li, Zhenzhen Ma, Huimin Ma, Zihan Wang, Haihai Liang, Jundong Jiao   +14 more
wiley   +1 more source

Formulation and optimization of upadacitinib-loaded transdermal patches for rheumatoid arthritis with zero-order release kinetics

Journal of Applied Pharmaceutical Research
Background: To develop and optimize Upadacitinib-loaded transdermal patches for rheumatoid arthritis treatment with improved patient compliance and sustained drug delivery.
Shubham Talole, Rahul Godge, Nikita Tambe, Nikita Mhase   +3 more
doaj   +1 more source