Results 81 to 90 of about 612,532 (342)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Wide-range instrument monitors flow rates of chemically active fluids [PDF]

, 1966
In-like transducers system measures flow rate of chemically active propellant fluids. The system uses one low-flow transducer and one high-flow transducer.

core   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Effects of Long-Term and Acute Hindlimb Unloading Model on Neuroelectrophysiological Signals of Hippocampal Interneurons and Pyramidal Cells Using Microelectrode Arrays

IEEE Access, 2020
Microgravity is the key environment of weightlessness experienced by all astronauts during spaceflights that cause severe physiological alterations in the human body. The effect of microgravity on the nervous system has not been elucidated. In this study,
Hao Wang, Juntao Liu, Zeying Lu, Shengwei Xu, Jingyu Xie, Yuchuan Dai, Guihua Xiao, Yilin Song, Yu Zhang, Lina Qu, Xinxia Cai   +10 more
doaj   +1 more source

Apparatus for disintegrating kidney stones [PDF]

, 1984
The useful life of the wire probe in an ultrasonic kidney stone disintegration instrument is enhanced and prolonged by attaching the wire of the wire probe to the tip of an ultrasonic transducer by means of a clamping arrangement.
Angulo, E. D.
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

High-Throughput Microelectrode Arrays for Precise Functional Localization of the Globus Pallidus Internus

Cyborg and Bionic Systems
The globus pallidus internus (GPi) was considered a common target for stimulation in Parkinson’s disease (PD). Located deep in the brain and of small size, pinpointing it during surgery is challenging.
Yuxin Zhu, Luyi Jing, Ruilin Hu, Fan Mo, Qianli Jia, Gucheng Yang, Zhaojie Xu, Meiqi Han, Mixia Wang, Xinxia Cai, Jinping Luo   +10 more
doaj   +1 more source

Modal analysis and nonlinear characterization of an airborne power ultrasonic transducer with rectangular plate radiator [PDF]

, 2018
Some industrial processes like particle agglomeration or food dehydration among others can be enhanced by the use of power ultrasonic technologies.
Acosta, V.M., Andrés, R.R., Lucas, M., Riera, E.   +3 more
core   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Study on Underwater Performance of Underwater Transducer Manufactured by 1-1-3 Piezoelectric Composite

Xibei Gongye Daxue Xuebao, 2019
A novel kind of underwater transducer with trapezoidal matching layer manufactured by 1-1-3 piezoelectric composite has been proposed to improve the underwater performance of high frequency transducer.

doaj   +1 more source