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Expanding the Genetic Landscape of Congenital Stationary Night Blindness Through the Analysis of Consanguineous Pakistani Families. [PDF]

open access: yesGenes (Basel)
Parveen R   +9 more
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Genetics of signal transduction in invertebrates

Current Opinion in Genetics & Development, 1994
Receptor tyrosine kinases regulate a number of different cell fate decisions during invertebrate development. Genetic analysis of the signal transduction pathways activated by these kinases suggests that they converge upon a common pathway involving Ras and a cascade of cytoplasmic kinases, diverging again in the nucleus with the regulation of specific
Dickson B, Hafen E
openaire   +4 more sources

Genetic approaches to mechanosensory transduction

Current Opinion in Neurobiology, 1995
Genetic approaches in several organisms provide the means of solving a previously intractable problem: characterizing the molecular foundations of the mechanical senses. In nematode mechanosensory cells, members of a novel class of epithelial ion channel subunits have been implicated as components of a mechanically gated channel.
M, Kernan, C, Zuker
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Genetic Approaches to Visual Transduction in Drosophila melanogaster

Receptors and Channels, 2003
Because almost everything we know about Drosophila phototransduction has come from studies based on genetic approaches, this review begins with a discussion of genetic approaches. We then present a brief overview of Drosophila phototransduction (section on Drosophila phototransduction: an overview) followed by a more detailed treatment of individual ...
William L, Pak, Hung-Tat, Leung
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Chemical genetic analysis of signal transduction pathways

Expert Opinion on Therapeutic Targets, 2006
Covalent modification of proteins by phosphorylation represents a major mechanism of signal transduction that contributes to many physiological and pathophysiological processes. The enzymes that regulate protein phosphorylation (e.g., protein kinases and phosphatases) are, therefore, potential targets for the rational design of small-molecule drugs for
Anja, Jaeschke, Roger J, Davis
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