Results 241 to 250 of about 626,396 (286)
CAR Therapies: Ex Vivo and In Vivo Potential of Exosomes and Biomimetic Nanoparticles. [PDF]
Cancers (Basel)Tkachenko E +10 more
europepmc +1 more source
Cell Surface Thiol Engineering Mechanoregulates Myogenic Differentiation via the FAK–PI3K–AKT Axis
Advanced Healthcare Materials, EarlyView.Schematic diagram illustrating how cell surface modification of skeletal muscle progenitor cells through TCEP treatment reveals enhanced cell adhesion, intracellular tension, and myogenesis at 19.66 kPa stiffness, leading to optimal cell fusion. In contrast, no significant changes are observed in the softer (10.61 kPa) or stiffer (49.4 kPa) matrices ...
Juyeon Kim +10 more
wiley +1 more source
The predawn dilemma in adeno-associated virus-based gene therapies for hereditary deafness. [PDF]
Am J Stem CellsZhou J, Deng D, Gan C, Du J, Zhao Y.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Radiotherapy damages bone and disrupts osteocyte function, yet mechanically mediated protection remains largely unexplored. This study demonstrates that low‐magnitude, high‐frequency (LMHF) vibration mitigates irradiated osteocyte apoptosis, restores their ability to regulate breast cancer extravasation, and acts synergistically with radiotherapy to ...
Xin Song +7 more
wiley +1 more source
Immune responses in retinal gene therapy: challenges, mechanisms, and future strategies. [PDF]
Front ImmunolMa Y, Shen Y.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans +11 more
wiley +1 more source
Efficient kidney gene transfer and proximal tubule transduction using self-complementary AAV.cc47 vectors. [PDF]
Mol Ther Methods Clin DevPeek JL +8 more
europepmc +1 more source
Geometrically Tunable Scaffold‐Free Muscle Bioconstructs for Treating Volumetric Muscle Loss
Advanced Healthcare Materials, EarlyView.Volumetric muscle loss is associated with traumatic muscle resulting in permanent functional impairment. Mold‐based, scaffold‐free, high‐density muscle tissue bioconstructs are developed in customizable geometric shapes and sizes. The transplanted rectangular solid‐shaped muscle bioconstructs improved muscle force recovery and tissue regeneration in ...
Bugra Ayan +8 more
wiley +1 more source
In vivo CAR cell therapy: from bench to bedside. [PDF]
J Hematol OncolXu J, Chen Z, Su L, Ren A, Mei H.
europepmc +1 more source
Bioprinting Organs—Science or Fiction?—A Review From Students to Students
Advanced Healthcare Materials, EarlyView.Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu +18 more
wiley +1 more source