Results 1 to 10 of about 70,529 (240)
Biophysical characterization of adeno-associated virus capsid through the viral transduction life cycle [PDF]
Journal of Genetic Engineering and Biotechnology, 2023 Adeno-associated virus (AAV) vectors have emerged as the leading delivery platforms for gene therapy. Throughout the life cycle of the virions, the capsid vector carries out diverse functions, ranging from cell surface receptor engagement, cellular entry, endosomal escape, nuclear import to new particle packaging, and assembly.
Yanqiao Shawn Xiang, Gang Hao
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Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction [PDF]
Cell Reports, 2019 Recent rapid progress in the field of mechanobiology has been driven by novel emerging tools and methodologies and growing interest from different scientific disciplines. Specific progress has been made toward understanding how cell mechanics is linked to intracellular signaling and the regulation of gene expression in response to a variety of ...
Charles D. Cox +2 more
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Signal-Induced Inhibition of Telomerase Activity in HL60 Cancer Cells by Signal Transduction Using the Biophysically Activated Regulative Molecule 31 (RM31): A Pilot Study [PDF]
Cureus, 2022 In this pilot study, we report the use of a novel, patented biophysical technology, which enables intranuclear access and cell nucleus stimulation, via the signal of the biophysically activated regulative molecule 31 (RM31). RM31 is the name of an isolated natural molecule found in the human body and is involved in many cellular mechanisms.
Claudia B Klein
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Unique Biophysical Properties of an Inward Proton Current that Mediates Sour Taste Transduction [PDF]
Biophysical Journal, 2016 Acidic solutions that are perceived as sour are detected by a subset of taste receptor cells on the tongue and palate epithelium that express the TRP channel PKD2L1. PKD2L1 does not form the sour receptor, but it can nonetheless serve as a molecular marker for sour taste receptor cells.
Wenlei Ye +2 more
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International Internal Medicine JournalAs a key mediator of chronic pain, neurotrophin nerve growth factor (NGF) binds to two neurotrophin receptors: p75 neurotrophin receptor (p75NTR) and tyrosine kinase receptor A (TrkA). The formation of the p75NTR-NGF-TrkA complex is implicated in the potentiation of chronic pain signals, making it an attractive target for therapeutic explorations.
Dek Kahin Yosef +3 more
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Expression and Characterization of Relaxin Family Peptide Receptor 1 Variants
Frontiers in Pharmacology, 2022 G-protein coupled receptors (GPCR) transduce extracellular stimuli into the cell interior and are thus centrally involved in almost all physiological-neuronal processes.
David Speck +11 more
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Frontiers in Endocrinology, 2022 In conjunction with the endothelin (ET) type A (ETAR) and type B (ETBR) receptors, angiotensin (AT) type 1 (AT1R) and type 2 (AT2R) receptors, are peptide-binding class A G-protein-coupled receptors (GPCRs) acting in a physiologically overlapping context.
David Speck +8 more
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Towards blueprints for network architecture, biophysical dynamics and signal transduction [PDF]
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2006 We review mathematical aspects ofbiophysical dynamics,signal transductionandnetwork architecturethat have been used to uncover functionally significant relations between the dynamics of single neurons and the networks they compose. We focus on examples that combine insights from these three areas to expand our understanding of systems neuroscience ...
Coombes, Stephen +3 more
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