Results 1 to 10 of about 170 (96)

Expression and Characterization of Relaxin Family Peptide Receptor 1 Variants

Frontiers in Pharmacology, 2022
G-protein coupled receptors (GPCR) transduce extracellular stimuli into the cell interior and are thus centrally involved in almost all physiological-neuronal processes.
David Speck, Gunnar Kleinau, Mark Meininghaus, Antje Erbe, Antje Erbe, Alexandra Einfeldt, Alexandra Einfeldt, Michal Szczepek, Patrick Scheerer, Patrick Scheerer, Vera Pütter, Vera Pütter   +11 more
doaj   +1 more source

Angiotensin and Endothelin Receptor Structures With Implications for Signaling Regulation and Pharmacological Targeting

Frontiers in Endocrinology, 2022
In conjunction with the endothelin (ET) type A (ETAR) and type B (ETBR) receptors, angiotensin (AT) type 1 (AT1R) and type 2 (AT2R) receptors, are peptide-binding class A G-protein-coupled receptors (GPCRs) acting in a physiologically overlapping context.
David Speck, Gunnar Kleinau, Michal Szczepek, Dennis Kwiatkowski, Rusan Catar, Aurélie Philippe, Aurélie Philippe, Patrick Scheerer, Patrick Scheerer   +8 more
doaj   +1 more source

Phytochromes in Agrobacterium fabrum

Frontiers in Plant Science, 2021
The focus of this review is on the phytochromes Agp1 and Agp2 of Agrobacterium fabrum. These are involved in regulation of conjugation, gene transfer into plants, and other effects. Since crystal structures of both phytochromes are known, the phytochrome
Tilman Lamparter, Peng Xue, Afaf Elkurdi, Gero Kaeser, Luisa Sauthof, Patrick Scheerer, Norbert Krauß   +6 more
doaj   +1 more source

Identification of Alternative Polyadenylation in Cyanidioschyzon merolae Through Long-Read Sequencing of mRNA

Frontiers in Genetics, 2022
Alternative polyadenylation (APA) is widespread among metazoans and has been shown to have important impacts on mRNA stability and protein expression. Beyond a handful of well-studied organisms, however, its existence and consequences have not been well ...
Leonard Schärfen, Dagmar Zigackova, Kirsten A. Reimer, Martha R. Stark, Viktor A. Slat, Nancy J. Francoeur, Melissa L. Wells, Lecong Zhou, Perry J. Blackshear, Karla M. Neugebauer, Stephen D. Rader   +10 more
doaj   +1 more source

The significant role of biophysics in cancer prevention: An overview [PDF]

EPJ Web of Conferences
Cancer is a dynamic, multifaceted illness caused by the abnormal growth of cells. The affected cells developed uncontrollably and destroyed various tissues. This deadly disease has become an important health issue worldwide.
Saha Rituparna, Mukherjee Pratap
doaj   +1 more source

High-Resolution Plasma Membrane-Selective Imaging by Second Harmonic Generation

iScience, 2018
Summary: The plasma membrane is the site of intercellular communication and subsequent intracellular signal transduction. The specific visualization of the plasma membrane in living cells, however, is difficult using fluorescence-based techniques owing ...
Takaha Mizuguchi, Masato Yasui, Mutsuo Nuriya   +2 more
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Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules

iScience, 2022
Summary: The G protein-coupled receptor 84 (GPR84) is found in immune cells and its expression is increased under inflammatory conditions. Activation of GPR84 by medium-chain fatty acids results in pro-inflammatory responses.
Amadeus Samuel Schulze, Gunnar Kleinau, Rosanna Krakowsky, David Rochmann, Ranajit Das, Catherine L. Worth, Petra Krumbholz, Patrick Scheerer, Claudia Stäubert   +8 more
doaj   +1 more source

Lrp, a global regulator, regulates the virulence of Vibrio vulnificus

Journal of Biomedical Science, 2017
Background An attenuated mutant (designated NY303) of Vibrio vulnificus, which causes serious wound infection and septicemia in humans, was isolated fortuitously from a clinical strain YJ016.
Yu-Chi Ho, Feng-Ru Hung, Chao-Hui Weng, Wei-Ting Li, Tzu-Hung Chuang, Tsung-Lin Liu, Ching-Yuan Lin, Chien-Jung Lo, Chun-Liang Chen, Jen-Wei Chen, Masayuki Hashimoto, Lien-I Hor   +11 more
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Structural snapshot of a bacterial phytochrome in its functional intermediate state

Nature Communications, 2018
Phytochromes are photoreceptors that are present in plants, bacteria and fungi. Here the authors present crystal structures of the phytochrome Agp2 from Agrobacterium fabrum in the parent Pfr state as well as a functional Meta-F intermediate and discuss ...
Andrea Schmidt, Luisa Sauthof, Michal Szczepek, Maria Fernandez Lopez, Francisco Velazquez Escobar, Bilal M. Qureshi, Norbert Michael, David Buhrke, Tammo Stevens, Dennis Kwiatkowski, David von Stetten, Maria Andrea Mroginski, Norbert Krauß, Tilman Lamparter, Peter Hildebrandt, Patrick Scheerer   +15 more
doaj   +1 more source

Structural–Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work

Frontiers in Endocrinology, 2017
The thyroid-stimulating hormone receptor (TSHR) is a member of the glycoprotein hormone receptors, a sub-group of class A G-protein-coupled receptors (GPCRs).
Gerd Krause, Gunnar Kleinau, Gunnar Kleinau, Catherine L. Worth, Annika Kreuchwig, Heike Biebermann, Patrick Marcinkowski, Patrick Scheerer   +7 more
doaj   +1 more source