Results 91 to 100 of about 35,843 (287)

The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis

eLife, 2015
Little is known on post-transcriptional regulation of adult and embryonic stem cell maintenance and differentiation. Here we characterize the role of Ddb1, a component of the CUL4-DDB1 ubiquitin ligase complex.
Jie Gao, Shannon M Buckley, Luisa Cimmino, Maria Guillamot, Alexandros Strikoudis, Yong Cang, Stephen P Goff, Iannis Aifantis   +7 more
doaj   +1 more source

Energy flow in biological system: Bioenergy transduction of V1-ATPase molecular rotary motor from E. hirae [PDF]

Progress in Biophysics and Molecular Biology 130, Part A, 33-38 (2017), 2017
We classify research fields in biology into those on flows of materials, energy, and information. As a representative energy transducing machinery in biology, our research target, V1-ATPase from a bacterium Enterococcus hirae, a typical molecular rotary motor is introduced.
arxiv  

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

Structures and functions of cilia during vertebrate embryo development

Molecular Reproduction and Development, Volume 89, Issue 12, Page 579-596, December 2022., 2022
Abstract Cilia are hair‐like structures that project from the surface of cells. In vertebrates, most cells have an immotile primary cilium that mediates cell signaling, and some specialized cells assemble one or multiple cilia that are motile and beat synchronously to move fluids in one direction.
Jeffrey D. Amack
wiley   +1 more source

Molecular principles underlying aggressive cancers

Signal Transduction and Targeted Therapy
Aggressive tumors pose ultra-challenges to drug resistance. Anti-cancer treatments are often unsuccessful, and single-cell technologies to rein drug resistance mechanisms are still fruitless.
Ruth Nussinov, Bengi Ruken Yavuz, Hyunbum Jang   +2 more
doaj   +1 more source

Non-Functional Trace Amine-Associated Receptor 1 Variants in Patients With Mental Disorders

Frontiers in Pharmacology, 2019
Background: The G protein–coupled receptor (GPCR) trace amine-associated receptor 1 (TAAR1) is expressed across brain areas involved in emotions, reward and cognition, and modulates monoaminergic and glutamatergic neurotransmissions.
Grazia Rutigliano, Grazia Rutigliano, Julia Bräunig, Claudia Del Grande, Vittoria Carnicelli, Isabella Masci, Sergio Merlino, Gunnar Kleinau, Luca Tessieri, Simone Pardossi, Sarah Paisdzior, Liliana Dell’Osso, Heike Biebermann, Riccardo Zucchi   +13 more
doaj   +1 more source

Graphene deflectometry for sensing molecular processes at the nanoscale [PDF]

arXiv, 2018
Single-molecule sensing is at the core of modern biophysics and nanoscale science, from revolutionizing healthcare through rapid, low-cost sequencing to understanding various physical, chemical, and biological processes at their most basic level. However, important processes at the molecular scale are often too fast for the detection bandwidth or ...
arxiv  

Hydrogel‐Based Smart Materials for Wound Healing and Sensing

Aggregate, EarlyView.
The graphical abstract illustrates the role of hydrogel‐based flexible materials in advancing biomedical applications, including wound healing, point‐of‐care diagnostics, smart patches, and wearable devices. Hydrogels are particularly promising in modern wound care due to their high‐water content, flexibility, and biocompatibility.
Thi Kim Ngan Duong, Thi Thuy Truong, Thi Nhat Linh Phan, Thi Xuan Nguyen, Vu Hoang Minh Doan, Truong Tien Vo, Jaeyeop Choi, Umapada Pal, Prodyut Dhar, Byeongil Lee, Junghwan Oh, Sudip Mondal   +11 more
wiley   +1 more source

Advances in analytical microfluidic workflows for differential cancer diagnosis

Nano Select, Volume 4, Issue 1, Page 1-47, January 2023., 2023
Microfluidics holds a great potential for an analytical examination of liquid biopsy and the development of point‐of‐care testing devices. This review overviews fundamentals and technological breakthroughs of immunolabeled and label‐free analytical microfluidic devices for screening and examining CTCs, describes engineering‐driven workflows for ...
Morteza Hasanzadeh Kafshgari, Oliver Hayden   +1 more
wiley   +1 more source

Advanced Contactless Bioassembly Approaches: Leveraging Sound, Optical, and Magnetic Fields

Advanced NanoBiomed Research, EarlyView.
This review explores innovative contactless bioassembly techniques driven by sound, light, and magnetic fields, which enable the precise organization of cells, biomaterials, and bioactive substances into complex 3D structures. These technologies, crucial for in vitro modeling and regenerative medicine, are examined in detail, highlighting their ...
Micaela Natta, Greta Cocchi, Riccardo Tognato, Alessandro Cianciosi, Tiziano Serra   +4 more
wiley   +1 more source