Results 111 to 120 of about 34,099 (218)

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Sequential ultrasound‐driven dynamic control of macrophage polarization combined with hydrogel for mechano‐chemical synergistic tissue repair

Interdisciplinary Medicine, EarlyView.
This study presents an innovative therapeutic strategy that integrates sequential ultrasound therapy with an injectable oxidized dextran‐metformin (ODE‐Met) hydrogel to dynamically regulate macrophage polarization and promote angiogenesis for inflamed tissue repair.
Fulong Man, Kun Wang, Zichen Yang, Lulu An, Caoyi You, Rongjie Li, Yanni Cai, Yang Li, Li Chen, Yiqiong Liu, Yan Li, Haiqing Dong, Yongyong Li   +12 more
wiley   +1 more source

Functional insights into the photoactive yellow protein family from homologs, multidomain proteins, and inferred <i>pyp</i> operons. [PDF]

J Bacteriol
Dohmen RL, Hoogerwerf G, Dohmen AJ, Neal ML, Bradley C, Huffman C, Teeman SM, Hampton SF, Powell S, Gunn Z, Hoff WD.   +10 more
europepmc   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Biophysics in the Czech Republic: 70th anniversary of the institute of biophysics. [PDF]

Eur Biophys J
Bártová E, Kozubek S, Kovařík A.
europepmc   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Lower Plasma Antioxidant Defense and Heat Shock Proteins Mark Intra‐Amniotic Sludge Ultrasound Finding

Journal of Ultrasound in Medicine, EarlyView.
Objectives Intra‐amniotic sludge is an independent risk factor for preterm birth. It consists of a biophysical sonographic finding in the amniotic fluid, formed by dense echogenic particles near the cervical internal orifice, due to sterile or infectious inflammatory processes.
Clarissa Chavez Ortiz Roberto, Lílian Corrêa Costa‐Beber, Lucas Machado Sulzbacher, Jaíne Borges dos Santos, Anna Karolina Kretschmann Florencio de Souza Bagetti, Eduardo Becker Jr, Matias Nunes Frizzo, Thiago Gomes Heck, Mirna Stela Ludwig   +8 more
wiley   +1 more source

Intracellular Ca²⁺ is not essential for SHH signaling but is promoted by Shh ligand in embryonic fibroblasts. [PDF]

BMC Mol Cell Biol
Shi X, Wang Z, Li S, Pan Y, Shen B, Liu S.   +5 more
europepmc   +1 more source

Fiber Reinforcement of Soft Spider Silk Hydrogels

Macromolecular Rapid Communications, EarlyView.
Along the development of matrices for biomedical applications, precise tuning of the biomaterial to interact with specific cell types/tissues is essential. The fabrication of fiber mesh‐reinforced soft hydrogels made of recombinant spider silk proteins allows for the adjustment of mechanical properties and hydrogel porosity, leading to improved cell ...
Christina Heinritz, Thomas Scheibel
wiley   +1 more source

Protein-Ligand Interactions: Recent Advances in Biophysics, Biochemistry, and Bioinformatics. [PDF]

Int J Mol Sci
Sedov IA, Zuev YF.
europepmc   +1 more source