Results 121 to 130 of about 70,628 (338)

Canonical and non-canonical integrin-based adhesions dynamically interconvert

Nature Communications
Adhesions are critical for anchoring cells in their environment, as signaling platforms and for cell migration. In line with these diverse functions different types of cell-matrix adhesions have been described.
Fabian Lukas, Claudia Matthaeus, Tania López-Hernández, Ines Lahmann, Nicole Schultz, Martin Lehmann, Dmytro Puchkov, Jan Pielage, Volker Haucke, Tanja Maritzen   +9 more
doaj   +1 more source

Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine

Advanced Science, EarlyView.
Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei, Chi Wang, Xiangyan Chen, Yuanyuan Zhu, Mei Yang, Ningxi Li, Honglin Huang, Guangjian Zhang, Mingzhen Zhang, Yiyao Liu, Rui Gao   +10 more
wiley   +1 more source

Interfacial Stress Regulates Plasticity and Drug Resistance at the Breast Cancer‐Host Interface

Advanced Science, EarlyView.
Drop‐on‐demand printing is used to replicate the spatial compartmentalization of the breast cancer‐host interface. Hydrogel confinement affects phenotypic changes in cells at the spheroid interface that drives a two‐fold increase in chemotherapeutic resistance compared to control unconfined spheroids.
Bram G. Soliman, Peilin Tian, Jiuyu Cui, Kristopher A. Kilian, J. Justin Gooding   +4 more
wiley   +1 more source

Biomolecular Interaction Prediction: The Era of AI

Advanced Science, EarlyView.
This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley   +1 more source

The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches

Cell Reports, 2019
Summary: In developing neurons, phosphoinositide 3-kinases (PI3Ks) control axon growth and branching by positively regulating PI3K/PI(3,4,5)P3, but how neurons are able to generate sufficient PI(3,4,5)P3 in the presence of high levels of the antagonizing
Annika Brosig, Joachim Fuchs, Fatih Ipek, Cristina Kroon, Sandra Schrötter, Mayur Vadhvani, Alexandra Polyzou, Julia Ledderose, Michiel van Diepen, Hermann-Georg Holzhütter, Thorsten Trimbuch, Niclas Gimber, Jan Schmoranzer, Ivo Lieberam, Christian Rosenmund, Christian Spahn, Patrick Scheerer, Michal Szczepek, George Leondaritis, Britta J. Eickholt   +19 more
doaj  

Editorial overview 'Network news: Reporting from the frontlines of cell signaling'. [PDF]

, 2020
Ablasser, Andrea, Thorner, Jeremy
core   +2 more sources

A Multifunctional Probe for Visualization of the Nanoscale Distribution of Cholesterol in Cells by Expansion Microscopy

Aggregate, EarlyView.
We develop an azido‐ and amino‐functionalized cholesterol probe that can be efficiently fixed and used for expansion microscopy (ExM). This cholesterol probe enables nanoscale tracking of cholesterol distribution dynamics in the endocytic pathway. Combining 10‐fold robust ExM and structured illumination microscopy allows us to resolve cholesterol ...
Gang Wen, Dominic A. Helmerich, Lisa Behringer‐Pließ, Markus Sauer   +3 more
wiley   +1 more source

Protocol to investigate G protein-coupled receptor signaling kinetics and concentration-dependent responses using ONE-GO biosensors

STAR Protocols
Summary: ONE vector G protein optical (ONE-GO) biosensors are versatile tools to measure the activity of G protein-coupled receptors (GPCRs) in cells. The availability of ONE-GO biosensors for ten active Gα subunits representative of all four G protein ...
Remi Janicot, Mikel Garcia-Marcos
doaj  

Advanced Contactless Bioassembly Approaches: Leveraging Sound, Optical, and Magnetic Fields

Advanced NanoBiomed Research, EarlyView.
This review explores innovative contactless bioassembly techniques driven by sound, light, and magnetic fields, which enable the precise organization of cells, biomaterials, and bioactive substances into complex 3D structures. These technologies, crucial for in vitro modeling and regenerative medicine, are examined in detail, highlighting their ...
Micaela Natta, Greta Cocchi, Riccardo Tognato, Alessandro Cianciosi, Tiziano Serra   +4 more
wiley   +1 more source

Nanostructured Biomaterial‐Based Approaches to Support Induced Pluripotent Stem Cell Differentiation

Advanced NanoBiomed Research, EarlyView.
Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic cells, represent an innovative approach for regenerative medicine and biomedical applications. This review highlights the importance of nanostructured biomaterials, utilized as delivery systems or scaffolds, in supporting iPSC differentiation and fate through structural and ...
Beatriz A. B. R. Passos, Matteo Battaglini, Gianni Ciofani   +2 more
wiley   +1 more source