Results 161 to 170 of about 70,628 (338)

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Myonuclear alterations associated with exercise are independent of age in humans

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Structural and mechanical properties of myonuclei in trained young and aged individuals. In skeletal muscle fibres from trained individuals, myonuclei are more spherical, have greater lamin A and are stiffer compared to untrained counterparts.
E. Battey, J. A. Ross, A. Hoang, D. G. S. Wilson, Y. Han, Y. Levy, R. D. Pollock, M. Kalakoutis, J. N. Pugh, G. L. Close, G. M. Ellison‐Hughes, N. R. Lazarus, T. Iskratsch, S. D. R. Harridge, J. Ochala, M. J. Stroud   +15 more
wiley   +1 more source

1G1510 Mechanisms of signal transduction activated by heavy-ion microbeam induced bystander responses(Cell Biology I,Oral Presentation,The 50th Annual Meeting of the Biophysical Society of Japan)

, 2012
Masanori Tomita, Hideki Matsumoto, Tomoo Funayama, Yuichiro Yokota, Kensuke Otsuka, Munetoshi Maeda, Yasuhiko Kobayashi   +6 more
openalex   +2 more sources

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, EarlyView.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

STCDB4ND: a signal transduction classification database for neurological diseases. [PDF]

Database (Oxford)
Gong B, Li S, Chen Y, Liu L, Hofestädt R, Chen M.   +5 more
europepmc   +1 more source

CTHRC1 promotes bone metastasis in prostate cancer

International Journal of Cancer, EarlyView.
What's New? The mechanisms driving bone metastasis in prostate cancer are still unclear, and predicting markers have not yet been identified. Based on the biological characterization of prostate cancer cell lines and integrated data analysis of clinical samples, the authors identified CTHRC1 as a candidate gene regulating prostate cancer bone ...
Yuichiro Sawada, Tadahiko Kikugawa, Tomoya Onishi, Osuke Arai, Hiroyuki Iio, Noriyoshi Miura, Shuhei Yoshida, Aoi Ikedo, Yuta Yanagihara, Noritaka Saeki, Iori Sakakibara, Balázs Győrffy, Takeshi Kishida, Yoichiro Okubo, Yoshiyasu Nakamura, Shinya Sato, Yohei Miyagi, Takashi Saika, Yuuki Imai   +18 more
wiley   +1 more source

2SBP-04 Structural basis for the glycan-processing mechanisms in glycoprotein quality control system(New Development of Structural Cell Biology in Signal Transduction,Symposium,The 52th Annual Meeting of the Biophysical Society of Japan(BSJ2014))

, 2014
Tadashi Satoh, Koichi Kato
openalex   +2 more sources

Editorial: Advanced biophysical and biochemical technologies to study GPCR signal transduction

Frontiers in Endocrinology
Maria Majellaro, Alexey Bondar, Alexey Bondar   +2 more
openaire   +3 more sources

MR‐Guidance of Gene Therapy for Brain Diseases: Moving From Palliative Treatment to Cures

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Regulatory bodies in the U.S. and Europe recently approved a gene therapy for aromatic L‐amino acid decarboxylase (AADC) deficiency, a rare neurologic disorder where a genetic mutation prevents dopamine production in the brain. Affected children fail to develop normal motor and cognitive functions.
Dalton H. Bermudez, Thomas Lilieholm, Walter F. Block   +2 more
wiley   +1 more source

Various anthracyclines exhibit differential cytotoxic effects related to CBR1-induced resistance in lung cancer cells. [PDF]

Med Oncol
Piska K, Koczurkiewicz-Adamczyk P, Kochanowski P, Bobis-Wozowicz S, Władyka B, Pękala E.   +5 more
europepmc   +1 more source