Results 161 to 170 of about 35,843 (287)

2SBP-01 Structural cell biology(New Development of Structural Cell Biology in Signal Transduction,Symposium,The 52th Annual Meeting of the Biophysical Society of Japan(BSJ2014))

, 2014
Toshio Hakoshima
openalex   +2 more sources

Half a century of biophysics: A comparison of presentation statistics from the 6th and 21st IUPAB Congresses. [PDF]

Biophys Physicobiol
Kataoka M, Nagayama K.
europepmc   +1 more source

2SBP-05 Structural Basis for Regulation of G Protein-activated Inwardly Rectifying Potassium Channel 1 (GIRK1) by G Proteins(New Development of Structural Cell Biology in Signal Transduction,Symposium,The 52th Annual Meeting of the Biophysical Society of Japan(BSJ2014))

, 2014
Masanori Osawa, Yoko Mase, Mariko Yokoagawa, Koh Takeuchi, Ichio Shimada   +4 more
openalex   +2 more sources

Evaluation of Benzo[cd]indol‐2(1H)‐ones as Downstream Hedgehog Pathway Inhibitors

ChemistryOpen, EarlyView.
Benzo[cd]indol‐2(1H)‐one 1 inhibits the Hedgehog signaling pathway downstream of Suppressor of Fused, lowering cellular and ciliary GLI2 levels, and preventing GLI1 expression. A PROTAC‐based competition assay validated the cellular engagement of BET bromodomains, adding compound 1 to the growing set of epigenetic modulators of the Hedgehog signaling ...
Ioannis A. Tsakoumagkos, Quentin T. L. Pasquer, Christian‐Louis Guillod, Charlotte Rossion, Meropi Bagka, Sonya Torche, Tomoyo Sakata‐Kato, James K. Chen, Sascha Hoogendoorn   +8 more
wiley   +1 more source

Monitoring Functional Posttranslational Modifications Using a Data‐Driven Proteome Informatic Pipeline

PROTEOMICS, EarlyView.
ABSTRACT Posttranslational modifications (PTMs) are of significant interest in molecular biomedicine due to their crucial role in signal transduction across various cellular and organismal processes. Characterizing PTMs, distinguishing between functional and inert modifications, quantifying their occupancies, and understanding PTM crosstalk are ...
Payman Nickchi, Uladzislau Vadadokhau, Mehdi Mirzaie, Marc Baumann, Amir A. Saei, Mohieddin Jafari   +5 more
wiley   +1 more source

Protocol for ecotropic pseudotyped lentiviral transduction of "murinized" human cells while decreasing risk of infection for laboratory personnel. [PDF]

STAR Protoc
Weber SLK, Heinzel T, Iyer-Bierhoff A.
europepmc   +1 more source

Unique Biophysical Properties of an Inward Proton Current that Mediates Sour Taste Transduction [PDF]

, 2016
Wenlei Ye, Jeremy D. Bushman, Emily R. Liman   +2 more
openalex   +1 more source

A family of bacterial actin homologs forms a three-stranded tubular structure. [PDF]

Proc Natl Acad Sci U S A
Bergeron JRC, Lale-Farjat SLM, Lewicka HM, Parry C, Kollman JM.   +4 more
europepmc   +1 more source

Enhancing Functional Protein Design Using Heuristic Optimization and Deep Learning for Anti‐Inflammatory and Gene Therapy Applications

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Protein sequence design is a highly challenging task, aimed at discovering new proteins that are more functional and producible under laboratory conditions than their natural counterparts. Deep learning‐based approaches developed to address this problem have achieved significant success.
Ayşenur Soytürk Patat, Özkan Ufuk Nalbantoğlu   +1 more
wiley   +1 more source

Co-infection of HSV-1 amplicons containing the XPC gene and a human artificial chromosome vector into primary XPC deficient fibroblast cells. [PDF]

Biochem Biophys Rep
Moralli D, Smith A, Garlick J, Kraemer KH, Monaco ZL.   +4 more
europepmc   +1 more source