Results 181 to 190 of about 34,099 (218)

The effect of enhancers on the lentiviral transduction efficiency in the human RPE cells: Insights for advancing retinal gene therapies. [PDF]

Biochem Biophys Rep
Najafi S, Rahimpour A, Ahmadieh H, Rezaei Kanavi M, Maleki Tehrani M, Suri F, Ranjbari J.   +6 more
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Correction for Jiang et al., Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Single-molecule localization microscopy reveals the molecular organization of endogenous membrane receptors. [PDF]

Sci Adv
Eiring P, Steinhardt MJ, Bauer N, Vogt C, Munawar U, Han S, Nerreter T, Einsele H, Kortüm KM, Doose S, Sauer M.   +10 more
europepmc   +1 more source

Ageing does not impair motor neuron adaptations: comparable motor unit responses to strength training in young and older adults

The Journal of Physiology, EarlyView.
Abstract figure legend Ageing is associated with reduced motor neuron excitability and lower motor unit (MU) discharge rates, contributing to impaired voluntary force production. Using high‐density surface EMG and longitudinal motor unit tracking, we show that 4 weeks of isometric strength training increases discharge rates and estimates of persistent ...
Andrea Casolo, Stefanie Del Vecchio, Benjamin I. Goodlich, Bastian Schrader, Stefano Nuccio, Edoardo Lecce, Ilenia Bazzucchi, Luca Angius, Francesco Felici, Joachim Schrader, Dario Farina, Alessandro Del Vecchio   +11 more
wiley   +1 more source

Microtubule-Dependent Ca²⁺ Spark Recruitment in the Heart. [PDF]

J Am Heart Assoc
Zhao G, Lederer WJ.
europepmc   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Potential role of <i>circ_WHSC1</i> and <i>miR-145-5p</i> in breast cancer promotion. [PDF]

Biochem Biophys Rep
Abtin M, Hosseinzadeh A, Nafisi N, Omranipour R, Sahebi L, Ahmadi M, Ghafouri-Fard S, Shakoori A.   +7 more
europepmc   +1 more source

Protein design and RNA design: Perspectives

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley   +1 more source

Miniaturized IL-2/anti-IL-2 immunocytokines selectively activate and support the <i>in vivo</i> persistence of regulatory T cells. [PDF]

Front Immunol
Fabilane CS, Tomala J, Zdinak PM, Chalmers BT, Stephenson AC, Ariail E, Teeley EC, Joglekar AV, Spangler JB.   +8 more
europepmc   +1 more source