Results 231 to 240 of about 35,843 (287)

Molecular mechanisms of hotspot variants in cytoskeletal β‐actin associated with Baraitser–Winter syndrome

open access: yesThe FEBS Journal, EarlyView.
Variants at position R196 in cytoskeletal β‐actin are the most common variants associated with Baraitser–Winter cerebrofrontofacial syndrome and result in craniofacial anomalies and neurodevelopmental disorders, most likely due to neuronal migration defects. This study explores the molecular mechanisms of p.R196 variants using purified proteins.
Johannes N. Greve, Dietmar J. Manstein
wiley   +1 more source

An adamantane‐based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation

open access: yesThe FEBS Journal, EarlyView.
Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a cationic thermosensory channel crucial for cold sensation and menthol response. TRPM8 dysfunction leads to sensory symptoms such as cold allodynia. Targeting TRPM8 is important for treating diseases like peripheral neuropathies and cancer.
Angela Lamberti   +9 more
wiley   +1 more source

Electric field promoted odontogenic differentiation of stem cells from apical papilla by remodelling cytoskeleton

open access: yesInternational Endodontic Journal, EarlyView.
Abstract Aim This study examined the impact of direct current electric fields (DCEFs) on the biological properties of stem cells derived from the apical papilla (SCAP) and further elucidated the underlying mechanisms involved in odontogenic differentiation induced by DCEFs stimulation.
Xiaolin Li   +7 more
wiley   +1 more source

Upregulation of utrophin improves the phenotype of Duchenne muscular dystrophy hiPSC-derived CMs. [PDF]

open access: yesMol Ther Nucleic Acids
Andrysiak K   +14 more
europepmc   +1 more source

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