Results 21 to 30 of about 70,628 (338)
Lentivector Transduction Improves Outcomes Over Transplantation of Human HSCs Alone in NOD/SCID/Fabry Mice [PDF]
, 2012 Fabry disease is a lysosomal storage disorder caused by a deficiency of a-galactosidase A (a-gal A) activity that results in progressive globotriaosylceramide (Gb(3)) deposition.
Au, Bryan C. Y. +7 more
core +1 more source
Lrp, a global regulator, regulates the virulence of Vibrio vulnificus
Journal of Biomedical Science, 2017 Background An attenuated mutant (designated NY303) of Vibrio vulnificus, which causes serious wound infection and septicemia in humans, was isolated fortuitously from a clinical strain YJ016.
Yu-Chi Ho +11 more
doaj +1 more source
Acoustically tunable optical transmission through a subwavelength hole with a bubble [PDF]
, 2017 Efficient manipulation of light with sound in subwavelength-sized volumes is important for applications in photonics, phononics, and biophysics, but remains elusive.
Greentree, A, Maksymov, I
core +1 more source
Structural snapshot of a bacterial phytochrome in its functional intermediate state
Nature Communications, 2018 Phytochromes are photoreceptors that are present in plants, bacteria and fungi. Here the authors present crystal structures of the phytochrome Agp2 from Agrobacterium fabrum in the parent Pfr state as well as a functional Meta-F intermediate and discuss ...
Andrea Schmidt +15 more
doaj +1 more source
Frontiers in Endocrinology, 2017 The thyroid-stimulating hormone receptor (TSHR) is a member of the glycoprotein hormone receptors, a sub-group of class A G-protein-coupled receptors (GPCRs).
Gerd Krause +7 more
doaj +1 more source
Capacitance fluctuations causing channel noise reduction in stochastic Hodgkin-Huxley systems [PDF]
, 2006 Voltage-dependent ion channels determine the electric properties of axonal cell membranes. They not only allow the passage of ions through the cell membrane but also contribute to an additional charging of the cell membrane resulting in the so-called ...
Adrian R H +22 more
core +3 more sources
Frontiers in Endocrinology, 2019 The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Nicolas Heyder +10 more
doaj +1 more source
The Architectural Dynamics of the Bacterial Flagellar Motor Switch
Biomolecules, 2020 The rotary bacterial flagellar motor is remarkable in biochemistry for its highly synchronized operation and amplification during switching of rotation sense. The motor is part of the flagellar basal body, a complex multi-protein assembly.
Shahid Khan
doaj +1 more source
Communications Biology, 2021 Junfeng Chen et al. examine potential functional consequences of reproduction timing-associated TSHR alleles segregating in Atlantic herring. By comparing fish that spawn during the spring to those that spawn in the autumn, they find that the spring ...
Junfeng Chen +13 more
doaj +1 more source
Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor
Frontiers in Pharmacology, 2018 The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design.
Noureldin Saleh +11 more
doaj +1 more source