Results 21 to 30 of about 170 (96)

Preventing excessive autophagy protects from the pathology of mtDNA mutations in Drosophila melanogaster

Nature Communications
Aberration of mitochondrial function is a shared feature of many human pathologies, characterised by changes in metabolic flux, cellular energetics, morphology, composition, and dynamics of the mitochondrial network.
Najla El Fissi, Florian A. Rosenberger, Kai Chang, Alissa Wilhalm, Tom Barton-Owen, Fynn M. Hansen, Zoe Golder, David Alsina, Anna Wedell, Matthias Mann, Patrick F. Chinnery, Christoph Freyer, Anna Wredenberg   +12 more
doaj   +1 more source

MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration

Molecular Neurodegeneration, 2021
Background MicroRNA (miRNA) expression in the brain is altered in neurodegenerative diseases. Recent studies demonstrated that selected miRNAs conventionally regulating gene expression at the post-transcriptional level can act extracellularly as ...
Thomas Wallach, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny, Drew Adler, Yuanyuan Zhai, Victor Kumbol, Omar Dzaye, Jutta Schüler, Matthias Futschik, Rolf Backofen, Patrick Scheerer, Seija Lehnardt   +18 more
doaj   +1 more source

Presence of the GFI1-36N single nucleotide polymorphism enhances the response of MLL-AF9 leukemic cells to CDK4/6 inhibition

Frontiers in Oncology, 2022
The zinc finger protein Growth Factor Independence 1 (GFI1) acts as a transcriptional repressor regulating differentiation of myeloid and lymphoid cells. A single nucleotide polymorphism of GFI1, GFI1-36N, has a prevalence of 7% in healthy Caucasians and
Jan Vorwerk, Kaiyan Sun, Daria Frank, Felix Neumann, Felix Neumann, Jana Hüve, Paulina Marie Budde, Longlong Liu, Xiaoqing Xie, Pradeep Kumar Patnana, Helal Mohammed Mohammed Ahmed, Bertram Opalka, Georg Lenz, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Cyrus Khandanpour, Cyrus Khandanpour   +19 more
doaj   +1 more source

Aluminum-Induced Entropy in Biological Systems: Implications for Neurological Disease

Journal of Toxicology, 2014
Over the last 200 years, mining, smelting, and refining of aluminum (Al) in various forms have increasingly exposed living species to this naturally abundant metal.
Christopher A. Shaw, Stephanie Seneff, Stephen D. Kette, Lucija Tomljenovic, John W. Oller, Robert M. Davidson   +5 more
doaj   +1 more source

Elastic analysis bridges structure and dynamics of an AAA+ molecular motor.

PLoS Computational Biology
Proteins carry out cellular functions by changing their structure among a few conformations, each characterised by a different energy level. Therefore, structural changes, energy transformations, and protein function are intimately related.
Victor Hugo Mello, Jiri Wald, Thomas C Marlovits, Pablo Sartori   +3 more
doaj   +1 more source

A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation

Biomolecules, 2022
Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role in mediating energy homeostasis. Mutations in the MC4R are the most frequent monogenic cause for obesity.
Nanina Reininghaus, Sarah Paisdzior, Friederike Höpfner, Sabine Jyrch, Cigdem Cetindag, Patrick Scheerer, Peter Kühnen, Heike Biebermann   +7 more
doaj   +1 more source

Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss

Frontiers in Aging Neuroscience, 2020
In the inner ear, cyclic guanosine monophosphate (cGMP) signaling has been described as facilitating otoprotection, which was previously observed through elevated cGMP levels achieved by phosphodiesterase 5 inhibition.
Philine Marchetta, Dorit Möhrle, Dorit Möhrle, Philipp Eckert, Katrin Reimann, Steffen Wolter, Arianna Tolone, Isabelle Lang, Markus Wolters, Robert Feil, Jutta Engel, François Paquet-Durand, Michaela Kuhn, Marlies Knipper, Lukas Rüttiger   +14 more
doaj   +1 more source

The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor

Frontiers in Pharmacology, 2018
Trace amine-associated receptors (TAARs) belong to the class A G-protein-coupled receptors (GPCR) and are evolutionary related to aminergic receptors. TAARs have been identified to mediate effects of trace amines.
Julia Bräunig, Juliane Dinter, Carolin S. Höfig, Sarah Paisdzior, Michal Szczepek, Patrick Scheerer, Mark Rosowski, Jens Mittag, Gunnar Kleinau, Gunnar Kleinau, Heike Biebermann   +10 more
doaj   +1 more source

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

eLife, 2018
The endoplasmic reticulum (ER) supports biosynthesis of proteins with diverse transmembrane domain (TMD) lengths and hydrophobicity. Features in transmembrane domains such as charged residues in ion channels are often functionally important, but could ...
Matthew J Shurtleff, Daniel N Itzhak, Jeffrey A Hussmann, Nicole T Schirle Oakdale, Elizabeth A Costa, Martin Jonikas, Jimena Weibezahn, Katerina D Popova, Calvin H Jan, Pavel Sinitcyn, Shruthi S Vembar, Hilda Hernandez, Jürgen Cox, Alma L Burlingame, Jeffrey L Brodsky, Adam Frost, Georg HH Borner, Jonathan S Weissman   +17 more
doaj   +1 more source

Protocol for live-cell Förster resonance energy transfer imaging to reveal the bistable insulin response of single C2C12-derived myotubes

STAR Protocols
Summary: Based on our hypothesis that myotubes exhibit a bistable response to insulin, here we present a protocol for finely measuring Akt phosphorylation in single myotubes under insulin stimulation.
Javed Akhtar, Muhammad Imran, Guanyu Wang   +2 more
doaj   +1 more source