Results 21 to 30 of about 35,843 (287)
Frontiers in Endocrinology, 2017 The thyroid-stimulating hormone receptor (TSHR) is a member of the glycoprotein hormone receptors, a sub-group of class A G-protein-coupled receptors (GPCRs).
Gerd Krause +7 more
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Communications Biology, 2021 Junfeng Chen et al. examine potential functional consequences of reproduction timing-associated TSHR alleles segregating in Atlantic herring. By comparing fish that spawn during the spring to those that spawn in the autumn, they find that the spring ...
Junfeng Chen +13 more
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Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor
Frontiers in Pharmacology, 2018 The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design.
Noureldin Saleh +11 more
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The Architectural Dynamics of the Bacterial Flagellar Motor Switch
Biomolecules, 2020 The rotary bacterial flagellar motor is remarkable in biochemistry for its highly synchronized operation and amplification during switching of rotation sense. The motor is part of the flagellar basal body, a complex multi-protein assembly.
Shahid Khan
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Acoustically tuneable optical transmission through a subwavelength hole with a bubble [PDF]
Phys. Rev. A 95, 033811 (2017), 2016 Efficient manipulation of light with sound in subwavelength-sized volumes is important for applications in photonics, phononics and biophysics, but remains elusive. We theoretically demonstrate the control of light with MHz-range ultrasound in a subwavelength, 300 nm wide water-filled hole with a 100 nm radius air bubble.
arxiv +1 more source
Frontiers in Endocrinology, 2019 The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Nicolas Heyder +10 more
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Thermodynamic and Kinetic Analysis of Sensitivity Amplification in Biological Signal Transduction [PDF]
Biophysical Chemistry, Vol. 105, pp. 585-593 (2003), 2002 Based on a thermodynamic analysis of the kinetic model for the protein phosphorylation-dephosphorylation cycle, we study the ATP (or GTP) energy utilization of this ubiquitous biological signal transduction process. It is shown that the free energy from hydrolysis inside cells, $\Delta G$ (phosphorylation potential), controls the amplification and ...
arxiv +1 more source
Cryo-EM captures early ribosome assembly in action
Nature Communications, 2023 The production of ribosomes is a precisely orchestrated energy consuming cellular process of highest priority. Here, the authors use cryo-EM to show that bacterial ribosomal subunits, self-assembled from their purified RNA and protein components, mature ...
Bo Qin +9 more
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Intramembrane Cavitation as a Predictive Bio-Piezoelectric Mechanism for Ultrasonic Brain Stimulation [PDF]
Phys. Rev. X 4, 011004 (2014), 2013 Low-intensity ultrasonic waves can remotely and nondestructively excite central nervous system (CNS) neurons. While diverse applications for this effect are already emerging, the biophysical transduction mechanism underlying this excitation remains unclear.
arxiv +1 more source
Information processing and signal integration in bacterial quorum sensing
Molecular Systems Biology, 2009 Bacteria communicate using secreted chemical signaling molecules called autoinducers in a process known as quorum sensing. The quorum‐sensing network of the marine bacterium Vibrio harveyi uses three autoinducers, each known to encode distinct ecological
Pankaj Mehta +4 more
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