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Single-Molecule Biophysical Techniques to Study Actomyosin Force Transduction
2020Inside the cellular environment, molecular motors can work in concert to conduct a variety of important physiological functions and processes that are vital for the survival of a cell. However, in order to decipher the mechanism of how these molecular motors work, single-molecule microscopy techniques have been popular methods to understand the ...
Yasuharu, Takagi +2 more
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Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2020
Signaling between cells can promote both the development and progression of cancer. It has been found that chemical and physical signals, together with extracellular factors, can influence cancer progression. In this review, we focus on the physical microenvironment of cancer cells and examine the action of mechanical, electromagnetic, thermal, and ...
XiaoLei, Huang +5 more
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Signaling between cells can promote both the development and progression of cancer. It has been found that chemical and physical signals, together with extracellular factors, can influence cancer progression. In this review, we focus on the physical microenvironment of cancer cells and examine the action of mechanical, electromagnetic, thermal, and ...
XiaoLei, Huang +5 more
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A biophysical approach towards an understanding of endotoxin-induced signal transduction
Journal of Endotoxin Research, 1999The purpose of our studies is to define the physicochemical parameters involved in the activation of host cells by endotoxin and to characterize the processes operative during endotoxin/membrane interaction with the aim of understanding transmembrane signal transduction mechanisms.
A.B. Schromm +6 more
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The insulin transduction system: A biophysical model for mitogenesis
International Journal of Quantum Chemistry, 1981A model has been proposed to account for many of the intracellular actions of insulin. This model is called the insulin transduction system and consists of coordinated stimulation by insulin of the sodium pump and the Na:H exchange system in the plasma membrane. The primary end result of stimulation of the insulin transduction system is an elevation of
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Advances in Biophysics, 2003
This work reviews recent achievements made by our lab. on intercellular signal transduction related to the synthesis and action of steroids. These achievements were made possible by the high suitability of cytochrome P450, a key enzyme in signal transduction, to quantitative spectroscopic analysis.
Suguru, Kawato +2 more
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This work reviews recent achievements made by our lab. on intercellular signal transduction related to the synthesis and action of steroids. These achievements were made possible by the high suitability of cytochrome P450, a key enzyme in signal transduction, to quantitative spectroscopic analysis.
Suguru, Kawato +2 more
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Tissue Engineering Part B: Reviews, 2015
The unique mechanoelectrochemical environment of cartilage has motivated researchers to investigate the effect of multiple biophysical cues, including mechanical, magnetic, and electrical stimulation, on chondrocyte biology. It is well established that biophysical stimuli promote chondrocyte proliferation, differentiation, and maturation within ...
Mariea A, Brady +2 more
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The unique mechanoelectrochemical environment of cartilage has motivated researchers to investigate the effect of multiple biophysical cues, including mechanical, magnetic, and electrical stimulation, on chondrocyte biology. It is well established that biophysical stimuli promote chondrocyte proliferation, differentiation, and maturation within ...
Mariea A, Brady +2 more
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Information Processing in Biochemical Networks.
Annual Review of BiophysicsLiving systems are characterized by controlled flows of matter, energy, and information. While the biophysics community has productively engaged with the first two, addressing information flows has been more challenging, with some scattered success in ...
G. Tkačik, P. R. T. Wolde
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Polymer sailing on rafts within lipid membranes
Proceedings of the National Academy of Sciences of the United States of AmericaSignificance Biopolymer adsorption and diffusion on cell membranes are vital for cellular processes such as signal transduction and disease development, including Alzheimer’s.
Jie Gao +5 more
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Biophysical and Molecular Features of Thermosensitive TRP Channels Involved in Sensory Transduction
2015Temperature is one of the physical variables that cells and biological organisms constantly monitor to achieve homeostasis and maintain chemical reactions at a suitable speed for the living environment to which they are adapted. In order to monitor and maintain temperature on a constant basis, thermosensitive molecules were selected during evolution ...
Gonzalo Ferreira +4 more
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Biophysical Chemistry of Signal Transduction
1999The concept of chemical signal transduction was originally developed for the regulatory coupling between extracellular hormones as the primary signal and intracellular second messenger molecules across the cell membrane. The cytosolic second messenger activation mediates the control of the kinase-catalyzed phosphorylations in the regulation of cell ...
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